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Aquaporin 4 (AQP4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS806536

Background Info: Detects ~35kDa. May detect larger glycosylated bands ~50kDa.Scientific Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they… More details

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Product Overview

Online Datasheet in PDF
Product Name
Aquaporin 4 (Aqp4), Polyclonal Antibody
Full Product Name
Aquaporin 4 Antibody: ATTO 390
Product Gene Name
anti-Aqp4 antibody
Product Synonym Names
AQP4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Matching Pairs
Unconjugated Antibody: Aquaporin 4 (MBS805441)
ATTO 390 Conjugated Antibody: Aquaporin 4 (MBS806536)
Matching Pairs
Unconjugated Antibody: N/A (MBS806536)
ATTO 390 Conjugated Antibody: Aquaporin 4 (MBS806536)
Molecular Weight
28,768 Da
3D Structure
ModBase 3D Structure for P47863
Conjugate
ATTO 390
Storage Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-Aqp4 antibody

Transporters
Applications Tested/Suitable for anti-Aqp4 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-Aqp4 antibody
1:1000-4000 (WB), 1:400 (IF)

Immunohistochemistry (IHC) of anti-Aqp4 antibody

Immunohistochemistry analysis using Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505). Tissue: kidney tissue. Species: Rat. Fixation: 4% paraformaldehyde-lysine-periodate. Primary Antibody: Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505) at 1:200 for 75 min at RT. Secondary Antibody: FITC Goat Anti-Rabbit (green) for 1 hour at RT. 4 um cryostat sections.
Rabbit Anti-AQP4 Polyclonal Antibody – Cat# MBS806536

Western Blot (WB) of anti-Aqp4 antibody

Western blot analysis of Rat kidney inner medullary homogenates showing detection of Aquaporin 4 protein using Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505). Primary Antibody: Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505) at 1:2000.
Rabbit Anti-AQP4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS806536

Product References and Citations for anti-Aqp4 antibody

1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396. 2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258. 3. Agre P., Nielsen S. (1996) Nephrologie. 17(7): 409-415. 4. Nagelhus E.A., Mathiisen T.M., Ottersen O.P. (2004) Neuroscience. 129(4): 905-913. 5. Lennon V.A., Kryzer T.J., Pittock S.J., Verkman A.S., Hinson S.R. (2005) J Exp Med. 202(4): 473- 477. 6. Bradl M., Lassmann D.H. (2008) Int. MS Journal/ MS Forum. 15(3): 75-78.

Other Notes

Small volumes of anti-Aqp4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Aqp4 purchase

MBS806536 is an antibody targeting Aqp4. Also known as Aquaporin 4 Antibody: ATTO 390. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Aqp4. It may not necessarily be applicable to this product.

NCBI GI #
6978531
NCBI GeneID
25293
NCBI Accession #
NP_036957.1
UniProt Primary Accession #
P47863
UniProt Related Accession #
P47863
GenBank Nucleotide #
NM_012825.4
NCBI Official Full Name
aquaporin-4 isoform 1
NCBI Official Synonym Full Names
aquaporin 4
NCBI Official Symbol
Aqp4
NCBI Official Synonym Symbols
Miwc; AQP-4; MIWC2
UniProt Protein Name
Aquaporin-4
UniProt Synonym Protein Names
Mercurial-insensitive water channel; MIWC; WCH4
Protein Family
Aquaporin
UniProt Gene Name
Aqp4
UniProt Synonym Gene Names
AQP-4; MIWC
UniProt Entry Name
AQP4_RAT
NCBI Protein Information
aquaporin-4; WCH4; mercurial-insensitive water channel

NCBI Summary for Aqp4

The protein encoded by this gene forms a water-specific channel that regulates body water balance, particularly in the brain. The encoded protein acts as a membrane-bound homotetramer, interacting with other proteins (MLC1, TRPV4, HEPACAM, and ATP1B1) to form a complex. Several variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
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UniProt Comments for Aqp4

AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described

Protein type: Channel, misc.; Transporter; Transporter, aquaporin family; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: protein complex; membrane; integral to plasma membrane; cell projection membrane; basolateral plasma membrane; T-tubule; cytoplasm; plasma membrane; basal plasma membrane; intercellular junction; sarcolemma; external side of plasma membrane

Molecular Function: water channel activity; porin activity; glycerol channel activity

Biological Process: glycerol transport; cellular water homeostasis; carbon dioxide transport; water transport; response to glucocorticoid stimulus; female pregnancy; negative regulation of interleukin-1 beta production; water homeostasis; response to radiation; sensory perception of sound; hyperosmotic salinity response; negative regulation of interleukin-6 production; multicellular organismal water homeostasis; transmembrane transport; protein homooligomerization
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Research Articles on Aqp4

1. The simulation studies showed a continuous movement of water in a single file across pore of unphosphorylated as well as phosphorylated rAQP4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Aqp4 antibody

 Reference Product  PubMed Publications
 Aqp2 antibody  >139 publications with Aqp4 and Aqp2
 Gfap antibody  >111 publications with Aqp4 and Gfap
 Aqp11 antibody  >15 publications with Aqp4 and Aqp11
 Il6 antibody  >7 publications with Aqp4 and Il6
 Aqp12b antibody  >1 publications with Aqp4 and Aqp12b
 Kcnj10 antibody  >1 publications with Aqp4 and Kcnj10

Pathways associated with anti-Aqp4 antibody

 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram

Diseases associated with anti-Aqp4 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >877 publications with Aqp4 and Nervous System Diseases
 Neuromyelitis Optica Antibodies  >521 publications with Aqp4 and Neuromyelitis Optica
 Brain Diseases Antibodies  >445 publications with Aqp4 and Brain Diseases
 Edema Antibodies  >439 publications with Aqp4 and Edema
 Brain Edema Antibodies  >375 publications with Aqp4 and Brain Edema
 Disease Models, Animal Antibodies  >195 publications with Aqp4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >172 publications with Aqp4 and Cardiovascular Diseases
 Inflammation Antibodies  >118 publications with Aqp4 and Inflammation
 Necrosis Antibodies  >42 publications with Aqp4 and Necrosis
 Kidney Diseases Antibodies  >38 publications with Aqp4 and Kidney Diseases

Organs/Tissues associated with anti-Aqp4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >921 publications with Aqp4 and Brain
 Kidney Antibodies  >154 publications with Aqp4 and Kidney
 Eye Antibodies  >134 publications with Aqp4 and Eye
 Muscle Antibodies  >106 publications with Aqp4 and Muscle
 Lung Antibodies  >63 publications with Aqp4 and Lung
 Inner Ear Antibodies  >24 publications with Aqp4 and Inner Ear
 Colon Antibodies  >22 publications with Aqp4 and Colon
 Ovary Antibodies  >12 publications with Aqp4 and Ovary
 Pituitary Gland Antibodies  >7 publications with Aqp4 and Pituitary Gland
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