Receptor Alpha5 (GABA-A) Antibody – Mouse Monoclonal

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]

GABRA5: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q12

Cellular Component: cell junction; dendrite; integral to plasma membrane; plasma membrane; postsynaptic membrane

Molecular Function: chloride channel activity; extracellular ligand-gated ion channel activity; GABA receptor binding; GABA-A receptor activity; receptor activity; transporter activity

Biological Process: associative learning; behavioral fear response; brain development; gamma-aminobutyric acid signaling pathway; inner ear receptor cell development; negative regulation of neuron apoptosis; positive regulation of defense response to virus by host; sensory perception of sound; signal transduction; synaptic transmission; transmembrane transport; transport