Mouse Anti-NAV beta 2 Monoclonal Antibody – Cat# MBS807126

Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68. Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 ug. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4 degree C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa.

NAV beta 2 Antibody – Mouse Monoclonal

Name: NAV beta 2 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS807126
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS807126

NavBeta2 or Scn2B, plays a crucial role in the assembly, expression and functional modulation of the heterotrimeric complex of the sodium channel. The subunit, beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Nav beta 2, Monoclonal Antibody

Full Product Name

Mouse Anti-Mouse Nav beta 2 Monoclonal IgG2B

Product Gene Name

anti-Nav beta 2 antibody

Product Synonym Names

Sodium channel subunit beta-2 Antibody; Scn2b Antibody; UNQ326/PRO386 Antibody; Gm183 Antibody; Nav beta 2 Antibody: ATTO 594; Mouse Anti-Mouse NaVbeta2 Monoclonal, Clone S395-68; Anti- Nav beta2; Nav beta 2 Antibody

Clonality

Monoclonal

Isotype

IgG2B

Clone Number

S395-68

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Protein G Purified

Concentration

1 mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C

Molecular Weight

Detects ~40kDa.

3D Structure

ModBase 3D Structure for Q56A07

Immunogen

Fusion protein amino acids 1-215 (full-length) of mouse NavBeta2

Immunogen Species

Mouse

COA

A 1:100 dilution was sufficient for detection of NavBeta2 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Storage Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Conjugate

ATTO 594

Cellular Localization

Membrane

Product Categories/Family for anti-Nav beta 2 antibody

Neuroscience; Ion Channels; Sodium Channels; Voltage-Gated Sodium Channels

Applications Tested/Suitable for anti-Nav beta 2 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Application Notes for anti-Nav beta 2 antibody

Western Blot: 1:1000

Product References and Citations for anti-Nav beta 2 antibody

1. Genes and mapped phenotypes. (n.d.). Retrieved March 16, 2015, from http://www.ncbi.nlm.nih.gov/gene/6327 2. Eubanks J., Srinivasan J., Dinulos M.B., Disteche C.M., Catterall W.A. (1997) Neuroreport. 8(12): 2775-2779. 3. Riuro H., et al. (2013) Hum Mutat. 34(7): 961-966.

Other Notes

Small volumes of anti-Nav beta 2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nav beta 2 purchase

MBS807126 is an antibody targeting Nav beta 2. Also known as Mouse Anti-Mouse Nav beta 2 Monoclonal IgG2B. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Nav beta 2. It may not necessarily be applicable to this product.

NCBI GI #

67906204

NCBI GeneID

72821

NCBI Accession #

NP_001014761.1

UniProt Primary Accession #

Q56A07

UniProt Related Accession #

Q56A07

GenBank Nucleotide #

NM_001014761.2

NCBI Official Full Name

sodium channel subunit beta-2

NCBI Official Synonym Full Names

sodium channel, voltage-gated, type II, beta

NCBI Official Symbol

Scn2b

NCBI Official Synonym Symbols

Gm183; AI840361; 2810451E09Rik

UniProt Protein Name

Sodium channel subunit beta-2

UniProt Gene Name

Scn2b

UniProt Synonym Gene Names

Gm183

UniProt Entry Name

SCN2B_MOUSE

NCBI Protein Information

sodium channel subunit beta-2

UniProt Comments for Nav beta 2

SCN2B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Protein type: Membrane protein, integral

Cellular Component: integral to membrane; membrane; voltage-gated sodium channel complex

Molecular Function: sodium channel activity; sodium channel regulator activity; voltage-gated ion channel activity; voltage-gated sodium channel activity

Biological Process: cardiac muscle contraction; ion transport; response to pyrethroid; sodium ion transport; transport

Research Articles on Nav beta 2

1. This study demonistrated that scn2b gene expression in mouse dorsal raphe nucleus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Nav beta 2 antibody

Disease Name	Pubmed Publications
Arrhythmias, Cardiac Antibodies	>10 publications with Nav beta 2 and Arrhythmias, Cardiac
Heart Diseases Antibodies	>10 publications with Nav beta 2 and Heart Diseases
Seizures Antibodies	>7 publications with Nav beta 2 and Seizures
Heart Failure Antibodies	>3 publications with Nav beta 2 and Heart Failure
Disease Models, Animal Antibodies	>2 publications with Nav beta 2 and Disease Models, Animal
Nerve Degeneration Antibodies	>2 publications with Nav beta 2 and Nerve Degeneration
Ventricular Dysfunction, Left Antibodies	>1 publications with Nav beta 2 and Ventricular Dysfunction, Left
Fever Antibodies	>1 publications with Nav beta 2 and Fever
Neurobehavioral Manifestations Antibodies	>1 publications with Nav beta 2 and Neurobehavioral Manifestations
Prostatic Neoplasms Antibodies	>1 publications with Nav beta 2 and Prostatic Neoplasms

Organs/Tissues associated with anti-Nav beta 2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>15 publications with Nav beta 2 and Brain
Embryonic Tissue Antibodies	>1 publications with Nav beta 2 and Embryonic Tissue