Mouse Anti-NAV beta 3 Monoclonal Antibody – Cat# MBS807356

Western Blot analysis of Mouse Brain showing detection of ~40 kDa Nav Beta 3 protein using Mouse Anti-Nav Beta 3 Monoclonal Antibody, Clone S396-29. Lane 1: MW Ladder. Lane 2: Mouse Brain. Load: 20 ug. Primary Antibody: Mouse Anti-Nav Beta 3 Monoclonal Antibody at 1:1000 for 16 hours at 4 degree C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Predicted/Observed Size: ~40 kDa.

NAV beta 3 Antibody – Mouse Monoclonal

Name: NAV beta 3 Antibody; Monoclonal; Mouse; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS807356
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS807356

Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are… More details

$570 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nav beta 3, Monoclonal Antibody

Full Product Name

Mouse Anti-Rat Nav beta 3 Monoclonal IgG2B

Product Gene Name

anti-Nav beta 3 antibody

Product Synonym Names

Sodium channel subunit beta-3 Antibody; Scn3b Antibody; KIAA1158 Antibody; Nav beta 3 Antibody: RPE ; Mouse Anti-Rat NaVbeta3 Monoclonal, Clone S396-29; Anti-Nav beta 3; Nav beta 3 Antibody

Clonality

Monoclonal

Isotype

IgG2B

Clone Number

S396-29

Host

Mouse

Species Reactivity

Mouse, Rat

Purity/Purification

Protein G Purified

Concentration

1 mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C

Matching Pairs

Unconjugated Antibody: Nav beta 3 Clone #S396-29 (MBS807193)
RPE Conjugated Antibody: Nav beta 3 Clone #S396-29 (MBS807356)

Matching Pairs

Unconjugated Antibody: N/A (MBS807356)
RPE Conjugated Antibody: Nav beta 3 Clone #S396-29 (MBS807356)

Molecular Weight

Detects ~40kDa.

3D Structure

ModBase 3D Structure for Q9JK00

Immunogen

Fusion protein amino acids 1-215 (full-length) of rat NavBeta3

Immunogen Species

Rat

COA

A 1:100 dilution was sufficient for detection of NavBeta3 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Storage Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Conjugate

RPE

Cellular Localization

Membrane

Product Categories/Family for anti-Nav beta 3 antibody

Neuroscience; Ion Channels; Sodium Channels; Voltage-Gated Sodium Channels

Applications Tested/Suitable for anti-Nav beta 3 antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Application Notes for anti-Nav beta 3 antibody

Western Blot: 1:1000

Product References and Citations for anti-Nav beta 3 antibody

1. Genes and mapped phenotypes. (n.d.). Retrieved March 26, 2015, from http://www.ncbi.nlm.nih.gov/gene/?term=Q9jK00 2. Qu Y., et al. (2001) Mol Cell Neurosci. 18(5): 570-580. 3. Ishikawa T., et al. (2013) Circ J. 77(4): 956-967.

Other Notes

Small volumes of anti-Nav beta 3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nav beta 3 purchase

MBS807356 is an antibody targeting Nav beta 3. Also known as Mouse Anti-Rat Nav beta 3 Monoclonal IgG2B. Reactive in Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Nav beta 3. It may not necessarily be applicable to this product.

NCBI GI #

20806175

NCBI GeneID

245956

NCBI Accession #

NP_620797.1

UniProt Primary Accession #

Q9JK00

UniProt Related Accession #

Q9JK00

GenBank Nucleotide #

NM_139097.3

NCBI Official Full Name

sodium channel subunit beta-3

NCBI Official Synonym Full Names

sodium voltage-gated channel beta subunit 3

NCBI Official Symbol

Scn3b

NCBI Official Synonym Symbols

Scnb3

UniProt Protein Name

Sodium channel subunit beta-3

UniProt Gene Name

Scn3b

UniProt Entry Name

SCN3B_RAT

NCBI Protein Information

sodium channel subunit beta-3

NCBI Summary for Nav beta 3

voltage-sensitive sodium channel auxiliary subunit; modulates channel gating with distinct kinetics [RGD, Feb 2006]

UniProt Comments for Nav beta 3

SCN3B: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.

Protein type: Membrane protein, integral; Channel, sodium

Cellular Component: integral to membrane; plasma membrane; voltage-gated sodium channel complex; Z disc

Molecular Function: sodium channel regulator activity

Biological Process: cardiac muscle contraction; membrane depolarization; nervous system development; positive regulation of heart rate; sensory perception of pain; sodium ion transport

Research Articles on Nav beta 3

1. The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Nav beta 3 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>22 publications with Nav beta 3 and Heart Diseases
Congenital Abnormalities Antibodies	>5 publications with Nav beta 3 and Congenital Abnormalities
Brugada Syndrome 7 Antibodies	>5 publications with Nav beta 3 and Brugada Syndrome 7
Nervous System Diseases Antibodies	>4 publications with Nav beta 3 and Nervous System Diseases
Fever Antibodies	>2 publications with Nav beta 3 and Fever
Brain Diseases Antibodies	>2 publications with Nav beta 3 and Brain Diseases
Seizures Antibodies	>1 publications with Nav beta 3 and Seizures
Breast Neoplasms Antibodies	>1 publications with Nav beta 3 and Breast Neoplasms
Nerve Degeneration Antibodies	>1 publications with Nav beta 3 and Nerve Degeneration
Inflammation Antibodies	>1 publications with Nav beta 3 and Inflammation

Organs/Tissues associated with anti-Nav beta 3 antibody

Organ/Tissue Name	Pubmed Publications
Dorsal Root Ganglion Antibodies	>2 publications with Nav beta 3 and Dorsal Root Ganglion
Pancreas Antibodies	>1 publications with Nav beta 3 and Pancreas
Lung Antibodies	>1 publications with Nav beta 3 and Lung
Brain Antibodies	>1 publications with Nav beta 3 and Brain