GLUT2 Antibody – Rabbit Polyclonal

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues.

Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: basolateral plasma membrane; brush border membrane; cytosol; endosome; integral to plasma membrane; intercellular junction; membrane; plasma membrane

Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity; insulin receptor binding

Biological Process: carbohydrate metabolic process; carbohydrate utilization; endocrine pancreas development; energy reserve metabolic process; fructose transport; glucose transport; hexose transport; regulation of insulin secretion; response to glucose stimulus; response to peptide hormone stimulus; transmembrane transport

Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi-bickel Syndrome