UVRAG Antibody – Rabbit Polyclonal

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

UVRAG: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: centrosome; chromosome, pericentric region; cytoplasm; early endosome; endoplasmic reticulum; late endosome; lysosome; midbody; phagocytic vesicle

Molecular Function: protein binding; SH3 domain binding; SNARE binding

Biological Process: autophagy; centrosome organization and biogenesis; chromosome segregation; DNA repair; entry of virus into host cell; maintenance of Golgi localization; positive regulation of autophagy; receptor catabolic process; regulation of cytokinesis; retrograde vesicle-mediated transport, Golgi to ER; spindle organization and biogenesis