• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ARHGAP17 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820142

MBS820142 is an antibody targeting ARHGAP17. Reactive in Human, Dog. Host: Rabbit. Rabbit polyclonal antibody to ARHGAP17 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARHGAP17, Polyclonal Antibody
Full Product Name
Anti-ARHGAP17 Antibody
Product Gene Name
anti-ARHGAP17 antibody
Product Synonym Names
RICH1; Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Dog
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of ARHGAP17 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
ARHGAP17 peptide (MBS823600) is used for blocking the activity of ARHGAP17 antibody (MBS820142)
Molecular Weight
42,512 Da
OMIM
608293
3D Structure
ModBase 3D Structure for Q68EM7
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ARHGAP17. The exact sequence is proprietary.
Applications Tested/Suitable for anti-ARHGAP17 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemsitry (ICC)
Application Notes for anti-ARHGAP17 antibody
WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-ARHGAP17 antibody

Western blot analysis of ARHGAP17 expression in Lovo (A) whole cell lysates.
Rabbit Anti-ARHGAP17 Polyclonal Antibody – Cat# MBS820142

Immunofluorescence (IF) of anti-ARHGAP17 antibody

Immunofluorescent analysis of ARHGAP17 staining in Lovo cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-ARHGAP17 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS820142

Other Notes

Small volumes of anti-ARHGAP17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGAP17. It may not necessarily be applicable to this product.

NCBI GI #
54860079
NCBI GeneID
55114
NCBI Accession #
NP_001006635.1
UniProt Primary Accession #
Q68EM7
UniProt Secondary Accession #
Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54; A8K6M6
UniProt Related Accession #
Q68EM7
GenBank Nucleotide #
NM_001006634.2
NCBI Official Full Name
rho GTPase-activating protein 17 isoform 1
NCBI Official Synonym Full Names
Rho GTPase activating protein 17
NCBI Official Symbol
ARHGAP17
NCBI Official Synonym Symbols
PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH-1; MSTP038; MSTP066; MSTP110
UniProt Protein Name
Rho GTPase-activating protein 17
UniProt Synonym Protein Names
Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1
Protein Family
Rho GTPase-activating protein
UniProt Gene Name
ARHGAP17
UniProt Synonym Gene Names
RICH1; RICH-1
UniProt Entry Name
RHG17_HUMAN
NCBI Protein Information
rho GTPase-activating protein 17; rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs 1; neuron-associated developmentally regulated protein

NCBI Summary for ARHGAP17

RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

UniProt Comments for ARHGAP17

ARHGAP17: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: tight junction; plasma membrane; cytosol

Molecular Function: protein binding; SH3 domain binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
Show more

Research Articles on ARHGAP17

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARHGAP17 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Organs/Tissues associated with anti-ARHGAP17 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ARHGAP17 and Brain
 Nerve Antibodies  >3 publications with ARHGAP17 and Nerve
 Embryonic Tissue Antibodies  >2 publications with ARHGAP17 and Embryonic Tissue
 Blood Antibodies  >1 publications with ARHGAP17 and Blood
 Spleen Antibodies  >1 publications with ARHGAP17 and Spleen
 Kidney Antibodies  >1 publications with ARHGAP17 and Kidney
 Lung Antibodies  >1 publications with ARHGAP17 and Lung
 Placenta Antibodies  >1 publications with ARHGAP17 and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000