Septin 7 (SEP7) Antibody – Rabbit Polyclonal

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

SEPT7: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Belongs to the septin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cytoskeletal; Cell cycle regulation

Chromosomal Location of Human Ortholog: 7p14.2

Cellular Component: cell cortex; actin cytoskeleton; microtubule cytoskeleton; cytoplasm; apical plasma membrane; stress fiber; nucleolus; plasma membrane; spindle; synapse; nerve terminal; midbody; axoneme; nucleus; cleavage furrow

Molecular Function: identical protein binding; protein binding; GTP binding; structural molecule activity

Biological Process: mitosis; protein heterooligomerization; cytokinesis; shape changes of embryonic cells