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FCGR2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820241

MBS820241 is an antibody targeting FCGR2C. Also known as Anti-CD32c Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to CD32c More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD32c (FCGR2C), Polyclonal Antibody
Full Product Name
Anti-CD32c Antibody
Product Gene Name
anti-FCGR2C antibody
Product Synonym Names
CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD32
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of CD32c protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
CD32c peptide (MBS822426) is used for blocking the activity of CD32c antibody (MBS820241)
Molecular Weight
25,907 Da
OMIM
612169
3D Structure
ModBase 3D Structure for P31995
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD32c. The exact sequence is proprietary.
Applications Tested/Suitable for anti-FCGR2C antibody
Western Blot (WB)
Application Notes for anti-FCGR2C antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-FCGR2C antibody

Western blot analysis of CD32c expression in HEK293T (A), mouse lung (B) whole cell lysates.
(Predicted band size: 35 kD; Observed band size: 40 kD)
Rabbit Anti-FCGR2C Polyclonal Antibody – Cat# MBS820241

Other Notes

Small volumes of anti-FCGR2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR2C. It may not necessarily be applicable to this product.

NCBI GI #
126116592
NCBI GeneID
9103 (Human)
NCBI Accession #
NP_963857.3
UniProt Primary Accession #
P31995
UniProt Secondary Accession #
O00523; O00524; O00525
UniProt Related Accession #
P31995
GenBank Nucleotide #
NM_201563.5
NCBI Official Full Name
low affinity immunoglobulin gamma Fc region receptor II-c
NCBI Official Synonym Full Names
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
NCBI Official Symbol
FCGR2C
NCBI Official Synonym Symbols
CD32; FCG2; CD32C; CDW32; IGFR2; FCRIIC
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-c
UniProt Synonym Protein Names
CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD_antigen: CD32
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR2C
UniProt Synonym Gene Names
CD32; FCG2; IGFR2; IgG Fc receptor II-c; Fc-gamma-RIIc; FcRII-c
UniProt Entry Name
FCG2C_HUMAN
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-c; fc-gamma-RIIc; IgG Fc receptor II-c; Fc gamma receptor IIC; immunoglobulin G Fc receptor II-c

NCBI Summary for FCGR2C

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]
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UniProt Comments for FCGR2C

FCGR2C: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; IgG binding

Biological Process: immune response; signal transduction

Disease: Thrombocytopenic Purpura, Autoimmune
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Research Articles on FCGR2C

1. We report the discovery of allele-dependent expression of the activating FcgammaRIIc on B cells. Identical to FcgammaRIIb in the extracellular domain, FcgammaRIIc has a tyrosine-based activation motif in its cytoplasmic domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FCGR2C antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram

Diseases associated with anti-FCGR2C antibody

 Disease Name  Pubmed Publications
 Purpura, Thrombocytopenic, Idiopathic Antibodies  >2 publications with FCGR2C and Purpura, Thrombocytopenic, Idiopathic

Organs/Tissues associated with anti-FCGR2C antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with FCGR2C and Blood
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