SLC24A2 Antibody – Rabbit Polyclonal

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

SLC24A2: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p22.1

Cellular Component: integral to membrane; plasma membrane; intrinsic to plasma membrane

Molecular Function: protein dimerization activity; potassium ion binding; sodium ion binding; calcium, potassium:sodium antiporter activity; symporter activity; calcium channel activity; manganese ion binding; calcium ion binding; cadmium ion binding; nickel ion binding

Biological Process: cellular calcium ion homeostasis; visual perception; response to stimulus; ion transport; learning; transmembrane transport; potassium ion transport; memory