Urotensin 2 (UTS2) Antibody – Rabbit Polyclonal

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

UTS2: Highly potent vasoconstrictor. Belongs to the urotensin-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; receptor binding

Biological Process: response to drug; positive regulation of synaptic transmission, cholinergic; positive regulation of circadian sleep/wake cycle, REM sleep; negative regulation of heart rate; negative regulation of glomerular filtration; positive regulation of collagen biosynthetic process; positive regulation of heart rate; response to testosterone stimulus; positive regulation of vasodilation; negative regulation of insulin secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; muscle contraction; regulation of blood pressure; response to hypoxia; negative regulation of blood pressure; positive regulation of cell differentiation; positive regulation of blood pressure