NPAS2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

NPAS2: BMAL1-NPAS2 heterodimers activate E-box element (5'- CACGTG-3') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: transcription factor complex; nucleus; cytosol

Molecular Function: protein dimerization activity; signal transducer activity; protein binding; DNA binding; metal ion binding; Hsp90 protein binding; transcription factor activity

Biological Process: circadian rhythm; locomotor rhythm; circadian sleep/wake cycle; central nervous system development; positive regulation of DNA repair; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; response to redox state; circadian regulation of gene expression; cellular lipid metabolic process; signal transduction; response to DNA damage stimulus