Rabbit Anti-CCBE1 Polyclonal Antibody – Cat# MBS820565

Western blot analysis of CCBE1 expression in ACHN (A), HeLa (B), SP2/0 (C), PC12 (D) whole cell lysates.

CCBE1 Antibody – Rabbit Polyclonal

Name: CCBE1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS820565
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820565

MBS820565 is an antibody targeting CCBE1. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to CCBE1 More details

$225 / 0.03 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCBE1, Polyclonal Antibody

Full Product Name

Anti-CCBE1 Antibody

Product Gene Name

anti-CCBE1 antibody

Product Synonym Names

KIAA1983; Collagen and calcium-binding EGF domain-containing protein 1; Full of fluid protein homolog

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purity/Purification

The antibody was purified by immunogen affinity chromatography.

Specificity

Recognizes endogenous levels of CCBE1 protein.

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Antibody/Peptide Pairs

CCBE1 peptide (MBS823785) is used for blocking the activity of CCBE1 antibody (MBS820565)

Molecular Weight

22,600 Da

OMIM

phenotype 612753

3D Structure

ModBase 3D Structure for Q6UXH8

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CCBE1. The exact sequence is proprietary.

Applications Tested/Suitable for anti-CCBE1 antibody

Western Blot (WB)

Application Notes for anti-CCBE1 antibody

WB (1/500 - 1/1000)

Other Notes

Small volumes of anti-CCBE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCBE1. It may not necessarily be applicable to this product.

NCBI GI #

39930511

NCBI GeneID

147372

NCBI Accession #

NP_597716.1

UniProt Primary Accession #

Q6UXH8

UniProt Secondary Accession #

Q6MZX5; Q86SS2; Q8TF19

UniProt Related Accession #

Q6UXH8

GenBank Nucleotide #

NM_133459.3

NCBI Official Full Name

collagen and calcium-binding EGF domain-containing protein 1

NCBI Official Synonym Full Names

collagen and calcium binding EGF domains 1

NCBI Official Symbol

CCBE1

NCBI Official Synonym Symbols

HKLLS1

UniProt Protein Name

Collagen and calcium-binding EGF domain-containing protein 1

UniProt Synonym Protein Names

Full of fluid protein homolog

Protein Family

Collagen and calcium-binding EGF domain-containing protein

UniProt Gene Name

CCBE1

UniProt Synonym Gene Names

KIAA1983

UniProt Entry Name

CCBE1_HUMAN

NCBI Protein Information

collagen and calcium-binding EGF domain-containing protein 1; full of fluid protein homolog

NCBI Summary for CCBE1

This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]

UniProt Comments for CCBE1

CCBE1: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLLS). HLLS is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation. Belongs to the CCBE1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 18q21.32

Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen

Molecular Function: collagen binding; protease binding; calcium ion binding

Biological Process: positive regulation of angiogenesis; venous blood vessel morphogenesis; lymphangiogenesis; sprouting angiogenesis

Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 1

Research Articles on CCBE1

1. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCBE1 antibody

Reference Product	PubMed Publications
VEGFC antibody	>11 publications with CCBE1 and VEGFC
CCDC11 antibody	>1 publications with CCBE1 and CCDC11

Diseases associated with anti-CCBE1 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>5 publications with CCBE1 and Congenital Abnormalities
Hennekam lymphangiectasia lymphedema syndrome Antibodies	>5 publications with CCBE1 and Hennekam lymphangiectasia lymphedema syndrome
Edema Antibodies	>3 publications with CCBE1 and Edema
Hydrops Fetalis Antibodies	>3 publications with CCBE1 and Hydrops Fetalis
Intellectual Disability Antibodies	>3 publications with CCBE1 and Intellectual Disability
Neurobehavioral Manifestations Antibodies	>2 publications with CCBE1 and Neurobehavioral Manifestations
Abnormalities, Multiple Antibodies	>2 publications with CCBE1 and Abnormalities, Multiple
Inflammation Antibodies	>1 publications with CCBE1 and Inflammation
Liver Diseases Antibodies	>1 publications with CCBE1 and Liver Diseases
Lung Diseases Antibodies	>1 publications with CCBE1 and Lung Diseases

Organs/Tissues associated with anti-CCBE1 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>6 publications with CCBE1 and Embryonic Tissue
Bone Antibodies	>2 publications with CCBE1 and Bone
Liver Antibodies	>2 publications with CCBE1 and Liver
Ovary Antibodies	>1 publications with CCBE1 and Ovary
Prostate Antibodies	>1 publications with CCBE1 and Prostate
Intestine Antibodies	>1 publications with CCBE1 and Intestine
Lung Antibodies	>1 publications with CCBE1 and Lung
Bone Marrow Antibodies	>1 publications with CCBE1 and Bone Marrow