NP_005514.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,486 Da
NCBI Official Full Name
homeobox protein Hox-A11
NCBI Official Synonym Full Names
homeobox A11
NCBI Official Synonym Symbols
NCBI Protein Information
homeobox protein Hox-A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I
UniProt Protein Name
Homeobox protein Hox-A11
UniProt Synonym Protein Names
Homeobox protein Hox-1I
UniProt Synonym Gene Names
UniProt Entry Name
HXA11_HUMAN
NCBI Summary for HOXA11
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
UniProt Comments for HOXA11
HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: transcription factor complex; protein complex; nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: embryonic forelimb morphogenesis; developmental growth; anatomical structure morphogenesis; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; male gonad development; uterus development; anterior/posterior pattern formation; positive regulation of chondrocyte differentiation; dorsal/ventral pattern formation; ureteric bud branching; single fertilization; induction of an organ; mesodermal cell fate specification; spermatogenesis; embryonic digit morphogenesis; skeletal development; metanephros development; proximal/distal pattern formation; embryonic limb morphogenesis
Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia
Research Articles on HOXA11
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Products associated with anti-HOXA11 antibody
Pathways associated with anti-HOXA11 antibody
Diseases associated with anti-HOXA11 antibody
Organs/Tissues associated with anti-HOXA11 antibody
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