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ALDOA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820609

MBS820609 is an antibody targeting ALDOA. Reactive in Human, Mouse, Rat, Dog, Rabbit. Host: Rabbit. Rabbit polyclonal antibody to ALDOA More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALDOA, Polyclonal Antibody
Full Product Name
Anti-ALDOA Antibody
Product Gene Name
anti-ALDOA antibody
Product Synonym Names
ALDA; Fructose-bisphosphate aldolase A; Lung cancer antigen NY-LU-1; Muscle-type aldolase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog, Rabbit
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of ALDOA protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
ALDOA peptide (MBS823996) is used for blocking the activity of ALDOA antibody (MBS820609)
Molecular Weight
45,261 Da
OMIM
gene 611881
3D Structure
ModBase 3D Structure for P04075
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ALDOA. The exact sequence is proprietary.
Applications Tested/Suitable for anti-ALDOA antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemsitry (ICC), Immunoprecipitation (IP)
Application Notes for anti-ALDOA antibody
WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500), IP (1/10 - 1/100)

Western Blot (WB) of anti-ALDOA antibody

Western blot analysis of ALDOA expression in HEK293T (A), HepG2 (B), HeLa (C), NIH3T3 (D), PC12 (E), rat skeletal muscle (F) whole cell lysates.
Rabbit Anti-ALDOA Polyclonal Antibody – Cat# MBS820609

Immunofluorescence (IF) of anti-ALDOA antibody

Immunofluorescent analysis of ALDOA staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-ALDOA Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS820609

Other Notes

Small volumes of anti-ALDOA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDOA. It may not necessarily be applicable to this product.

NCBI GI #
4557305
NCBI GeneID
226
NCBI Accession #
NP_000025.1
UniProt Primary Accession #
P04075
UniProt Secondary Accession #
Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2; B4DXI7
UniProt Related Accession #
P04075
GenBank Nucleotide #
NM_000034.3
NCBI Official Full Name
fructose-bisphosphate aldolase A isoform 1
NCBI Official Synonym Full Names
aldolase A, fructose-bisphosphate
NCBI Official Symbol
ALDOA
NCBI Official Synonym Symbols
ALDA; GSD12; HEL-S-87p
UniProt Protein Name
Fructose-bisphosphate aldolase A
UniProt Synonym Protein Names
Lung cancer antigen NY-LU-1; Muscle-type aldolase
Protein Family
Fructose-bisphosphate aldolase
UniProt Gene Name
ALDOA
UniProt Synonym Gene Names
ALDA
UniProt Entry Name
ALDOA_HUMAN
NCBI Protein Information
fructose-bisphosphate aldolase A; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase; epididymis secretory sperm binding protein Li 87p

NCBI Summary for ALDOA

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]
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UniProt Comments for ALDOA

ALDOA: a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - pentose phosphate pathway; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.1.2.13; Lyase

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: I band; extracellular space; membrane; extracellular region; M band; cytosol; nucleus; actin cytoskeleton

Molecular Function: tubulin binding; identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; actin binding

Biological Process: platelet activation; glycolysis; striated muscle contraction; actin filament organization; glucose metabolic process; pathogenesis; protein homotetramerization; gluconeogenesis; muscle maintenance; regulation of cell shape; fructose 1,6-bisphosphate metabolic process; platelet degranulation; ATP biosynthetic process; carbohydrate metabolic process; blood coagulation; fructose metabolic process

Disease: Glycogen Storage Disease Xii
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Research Articles on ALDOA

1. ALDOA is highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALDOA antibody

 Reference Product  PubMed Publications
 GAPDH antibody  >8 publications with ALDOA and GAPDH
 PKM2 antibody  >6 publications with ALDOA and PKM2
 PFKP antibody  >4 publications with ALDOA and PFKP
 TKT antibody  >3 publications with ALDOA and TKT
 PFKL antibody  >2 publications with ALDOA and PFKL
 TPI1 antibody  >2 publications with ALDOA and TPI1
 GAPDHS antibody  >1 publications with ALDOA and GAPDHS
 PFKM antibody  >1 publications with ALDOA and PFKM

Pathways associated with anti-ALDOA antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram

Diseases associated with anti-ALDOA antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >5 publications with ALDOA and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with ALDOA and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >3 publications with ALDOA and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3 publications with ALDOA and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with ALDOA and Inflammation
 Liver Diseases Antibodies  >2 publications with ALDOA and Liver Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ALDOA and Cardiovascular Diseases
 Anemia Antibodies  >2 publications with ALDOA and Anemia
 Brain Diseases Antibodies  >2 publications with ALDOA and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with ALDOA and Nervous System Diseases

Organs/Tissues associated with anti-ALDOA antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >9 publications with ALDOA and Muscle
 Lung Antibodies  >7 publications with ALDOA and Lung
 Ovary Antibodies  >5 publications with ALDOA and Ovary
 Blood Antibodies  >4 publications with ALDOA and Blood
 Vascular Antibodies  >4 publications with ALDOA and Vascular
 Liver Antibodies  >3 publications with ALDOA and Liver
 Bone Antibodies  >2 publications with ALDOA and Bone
 Brain Antibodies  >2 publications with ALDOA and Brain
 Heart Antibodies  >1 publications with ALDOA and Heart
 Kidney Antibodies  >1 publications with ALDOA and Kidney
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