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Laminin Alpha 5 (LAMA5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820658

MBS820658 is an antibody targeting LAMA5. Also known as Anti-Laminin alpha 5 Antibody. Reactive in Human, Mouse. Host: Rabbit. Rabbit polyclonal antibody to Laminin alpha 5 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Laminin alpha 5 (LAMA5), Polyclonal Antibody
Full Product Name
Anti-Laminin alpha 5 Antibody
Product Gene Name
anti-LAMA5 antibody
Product Synonym Names
KIAA0533; KIAA1907; Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Laminin alpha 5 protein.
Preparation and Storage
Upon receipt aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
Laminin alpha 5 peptide (MBS822498) is used for blocking the activity of Laminin alpha 5 antibody (MBS820658)
OMIM
601033
3D Structure
ModBase 3D Structure for O15230
Entrez Gene
3911 (Human); 16776 (Mouse)
SwissProt
O15230 (Human); Q61001 (Mouse)
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Laminin alpha 5. The exact sequence is proprietary.
Applications Tested/Suitable for anti-LAMA5 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-LAMA5 antibody
WB: 1/500 - 1/1000
IHC: 1/100 - 1/200
IP: 1/10 - 1/100

Western Blot (WB) of anti-LAMA5 antibody

Western blot analysis of Laminin alpha 5 expression in JAR (A), A431 (B), RAW264.7 (C) whole cell lysates.
(Predicted band size: 399 kD; Observed band size: 400 kD)
Rabbit Anti-LAMA5 Polyclonal Antibody – Cat# MBS820658

Immunohistochemistry (IHC) of anti-LAMA5 antibody

Immunohistochemical analysis of Laminin alpha 5 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-LAMA5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS820658

Other Notes

Small volumes of anti-LAMA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LAMA5. It may not necessarily be applicable to this product.

NCBI GI #
21264602
NCBI GeneID
3911
NCBI Accession #
NP_005551.3
UniProt Primary Accession #
O15230
UniProt Secondary Accession #
Q8TDF8; Q8WZA7; Q9H1P1
UniProt Related Accession #
O15230
GenBank Nucleotide #
NM_005560.4
NCBI Official Full Name
laminin subunit alpha-5
NCBI Official Synonym Full Names
laminin, alpha 5
NCBI Official Symbol
LAMA5
UniProt Protein Name
Laminin subunit alpha-5
UniProt Synonym Protein Names
Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
Protein Family
Laminin
UniProt Gene Name
LAMA5
UniProt Synonym Gene Names
KIAA0533; KIAA1907
UniProt Entry Name
LAMA5_HUMAN
NCBI Protein Information
laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha

NCBI Summary for LAMA5

This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
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UniProt Comments for LAMA5

LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus

Molecular Function: integrin binding; structural molecule activity

Biological Process: regulation of cell adhesion; integrin-mediated signaling pathway; focal adhesion formation; endothelial cell differentiation; extracellular matrix organization and biogenesis; cell migration; muscle development; regulation of embryonic development; cytoskeleton organization and biogenesis; cell recognition; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; cell proliferation; extracellular matrix disassembly; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development
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Research Articles on LAMA5

1. Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LAMA5 antibody

 Reference Product  PubMed Publications
 LAMB2 antibody  >3 publications with LAMA5 and LAMB2
 ITGA3 antibody  >2 publications with LAMA5 and ITGA3
 ITGB1 antibody  >1 publications with LAMA5 and ITGB1
 BCAM antibody  >1 publications with LAMA5 and BCAM
 ITGA6 antibody  >1 publications with LAMA5 and ITGA6
 LAMB1 antibody  >1 publications with LAMA5 and LAMB1

Pathways associated with anti-LAMA5 antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with anti-LAMA5 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >6 publications with LAMA5 and Kidney Diseases
 Congenital Abnormalities Antibodies  >5 publications with LAMA5 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >3 publications with LAMA5 and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with LAMA5 and Breast Neoplasms
 Carcinoma Antibodies  >2 publications with LAMA5 and Carcinoma
 Inflammation Antibodies  >2 publications with LAMA5 and Inflammation
 Lung Diseases Antibodies  >1 publications with LAMA5 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with LAMA5 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >1 publications with LAMA5 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with LAMA5 and Neoplasms, Experimental

Organs/Tissues associated with anti-LAMA5 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >11 publications with LAMA5 and Kidney
 Embryonic Tissue Antibodies  >10 publications with LAMA5 and Embryonic Tissue
 Lung Antibodies  >6 publications with LAMA5 and Lung
 Vascular Antibodies  >6 publications with LAMA5 and Vascular
 Skin Antibodies  >5 publications with LAMA5 and Skin
 Placenta Antibodies  >3 publications with LAMA5 and Placenta
 Liver Antibodies  >3 publications with LAMA5 and Liver
 Mouth Antibodies  >2 publications with LAMA5 and Mouth
 Heart Antibodies  >2 publications with LAMA5 and Heart
 Spleen Antibodies  >1 publications with LAMA5 and Spleen
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