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NR2F6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820690

MBS820690 is an antibody targeting NR2F6. Reactive in Human, Mouse, Rat, Bovine, Dog, Pig. Host: Rabbit. Rabbit polyclonal antibody to NR2F6 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NR2F6, Polyclonal Antibody
Full Product Name
Anti-NR2F6 Antibody
Product Gene Name
anti-NR2F6 antibody
Product Synonym Names
EAR2; ERBAL2; Nuclear receptor subfamily 2 group F member 6; V-erbA-related protein 2; EAR-2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of NR2F6 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
NR2F6 peptide (MBS824206) is used for blocking the activity of NR2F6 antibody (MBS820690)
Molecular Weight
42,979 Da
OMIM
132880
3D Structure
ModBase 3D Structure for P10588
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NR2F6. The exact sequence is proprietary.
Applications Tested/Suitable for anti-NR2F6 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-NR2F6 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500), IP (1/10 - 1/100)

Western Blot (WB) of anti-NR2F6 antibody

Western blot analysis of TEL expression in CCRFCEM (A), Jurkat (B), K562 (C) whole cell lysates.
Rabbit Anti-NR2F6 Polyclonal Antibody – Cat# MBS820690

Immunohistochemistry (IHC) of anti-NR2F6 antibody

Immunohistochemical analysis of TEL staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-NR2F6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS820690

Immunofluorescence (IF) of anti-NR2F6 antibody

Immunofluorescent analysis of TEL staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
Rabbit Anti-NR2F6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS820690

Other Notes

Small volumes of anti-NR2F6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2F6. It may not necessarily be applicable to this product.

NCBI GI #
20070199
NCBI GeneID
2063
NCBI Accession #
NP_005225.2
UniProt Primary Accession #
P10588
UniProt Secondary Accession #
Q5XGA0; Q6P586; Q9BUE8; B2RC68
UniProt Related Accession #
P10588
GenBank Nucleotide #
NM_005234.3
NCBI Official Full Name
nuclear receptor subfamily 2 group F member 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 2, group F, member 6
NCBI Official Symbol
NR2F6
NCBI Official Synonym Symbols
EAR2; EAR-2; ERBAL2
UniProt Protein Name
Nuclear receptor subfamily 2 group F member 6
UniProt Synonym Protein Names
V-erbA-related protein 2; EAR-2
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR2F6
UniProt Synonym Gene Names
EAR2; ERBAL2; EAR-2
UniProt Entry Name
NR2F6_HUMAN
NCBI Protein Information
nuclear receptor subfamily 2 group F member 6; ERBA-related gene-2; V-erbA-related protein 2; nuclear receptor V-erbA-related; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2

UniProt Comments for NR2F6

EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; neuron development; gene expression; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter; detection of temperature stimulus involved in sensory perception of pain; signal transduction; entrainment of circadian clock by photoperiod
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Research Articles on NR2F6

1. EAR2/NR2F6 and related NRs such as the COUPTFs, TLX and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR2F6 antibody

 Reference Product  PubMed Publications
 NR1D1 antibody  >1 publications with NR2F6 and NR1D1
 RASD1 antibody  >1 publications with NR2F6 and RASD1

Pathways associated with anti-NR2F6 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR2F6 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with NR2F6 and Carcinoma
 Inflammation Antibodies  >2 publications with NR2F6 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with NR2F6 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >1 publications with NR2F6 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with NR2F6 and Brain Diseases
 Hyperplasia Antibodies  >1 publications with NR2F6 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with NR2F6 and Breast Neoplasms

Organs/Tissues associated with anti-NR2F6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with NR2F6 and Brain
 Liver Antibodies  >3 publications with NR2F6 and Liver
 Nerve Antibodies  >2 publications with NR2F6 and Nerve
 Bone Antibodies  >2 publications with NR2F6 and Bone
 Bone Marrow Antibodies  >1 publications with NR2F6 and Bone Marrow
 Placenta Antibodies  >1 publications with NR2F6 and Placenta
 Testis Antibodies  >1 publications with NR2F6 and Testis
 Muscle Antibodies  >1 publications with NR2F6 and Muscle
 Prostate Antibodies  >1 publications with NR2F6 and Prostate
 Kidney Antibodies  >1 publications with NR2F6 and Kidney
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