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VAV2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820717

MBS820717 is an antibody targeting VAV2. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to VAV2 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
VAV2, Polyclonal Antibody
Full Product Name
Anti-VAV2 Antibody
Product Gene Name
anti-VAV2 antibody
Product Synonym Names
Guanine nucleotide exchange factor VAV2; VAV-2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of VAV2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
VAV2 peptide (MBS824230) is used for blocking the activity of VAV2 antibody (MBS820717)
Molecular Weight
97,032 Da
OMIM
600428
3D Structure
ModBase 3D Structure for P52735
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human VAV2. The exact sequence is proprietary.
Applications Tested/Suitable for anti-VAV2 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemsitry (ICC), Immunoprecipitation (IP)
Application Notes for anti-VAV2 antibody
WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500), IP (1/10 - 1/100)

Western Blot (WB) of anti-VAV2 antibody

Western blot analysis of VAV2 expression in A431 (A), THP1 (B), NIH3T3 (C) whole cell lysates.
Rabbit Anti-VAV2 Polyclonal Antibody – Cat# MBS820717

Immunohistochemistry (IHC) of anti-VAV2 antibody

Rabbit Anti-VAV2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS820717

Immunofluorescence (IF) of anti-VAV2 antibody

Immunofluorescent analysis of VAV2 staining in THP1 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-VAV2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS820717

Other Notes

Small volumes of anti-VAV2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VAV2. It may not necessarily be applicable to this product.

NCBI GI #
197304715
NCBI GeneID
7410
NCBI Accession #
NP_001127870.1
UniProt Primary Accession #
P52735
UniProt Secondary Accession #
Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317; A2RUM4; A8MQ12; B6ZDF5
UniProt Related Accession #
P52735
GenBank Nucleotide #
NM_001134398.1
NCBI Official Full Name
guanine nucleotide exchange factor VAV2 isoform 1
NCBI Official Synonym Full Names
vav 2 guanine nucleotide exchange factor
NCBI Official Symbol
VAV2
NCBI Official Synonym Symbols
VAV-2
UniProt Protein Name
Guanine nucleotide exchange factor VAV2
Protein Family
Guanine nucleotide exchange factor
UniProt Gene Name
VAV2
UniProt Synonym Gene Names
VAV-2
UniProt Entry Name
VAV2_HUMAN
NCBI Protein Information
guanine nucleotide exchange factor VAV2; vav 2 oncogene

NCBI Summary for VAV2

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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UniProt Comments for VAV2

VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.

Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: plasma membrane; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding

Biological Process: lamellipodium biogenesis; platelet activation; axon guidance; cell migration; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; signal transduction; regulation of small GTPase mediated signal transduction; regulation of gene expression; small GTPase mediated signal transduction; regulation of blood coagulation; ephrin receptor signaling pathway; innate immune response; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway
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Research Articles on VAV2

1. Data suggest a coordination between paxillin kinase linker (PKL)/Vav2 signaling and PKL/beta-PIX signaling during cell migration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-VAV2 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram

Diseases associated with anti-VAV2 antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >7 publications with VAV2 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >5 publications with VAV2 and Inflammation
 Lung Neoplasms Antibodies  >5 publications with VAV2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with VAV2 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >4 publications with VAV2 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with VAV2 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with VAV2 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >2 publications with VAV2 and Weight Loss
 Kidney Diseases Antibodies  >2 publications with VAV2 and Kidney Diseases
 Edema Antibodies  >1 publications with VAV2 and Edema

Organs/Tissues associated with anti-VAV2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with VAV2 and Blood
 Lung Antibodies  >14 publications with VAV2 and Lung
 Brain Antibodies  >9 publications with VAV2 and Brain
 Kidney Antibodies  >8 publications with VAV2 and Kidney
 Liver Antibodies  >6 publications with VAV2 and Liver
 Nerve Antibodies  >6 publications with VAV2 and Nerve
 Thymus Antibodies  >4 publications with VAV2 and Thymus
 Intestine Antibodies  >3 publications with VAV2 and Intestine
 Skin Antibodies  >3 publications with VAV2 and Skin
 Prostate Antibodies  >3 publications with VAV2 and Prostate
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