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SLC22A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820928

MBS820928 is an antibody targeting SLC22A3. Also known as Anti-OCT3 Antibody. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to 41915 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OCT3 (SLC22A3), Polyclonal Antibody
Full Product Name
Anti-OCT3 Antibody
Product Gene Name
anti-SLC22A3 antibody
Product Synonym Names
EMTH; OCT3; Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of OCT3 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
OCT3 peptide (MBS822865) is used for blocking the activity of OCT3 antibody (MBS820928)
Molecular Weight
61,280 Da
OMIM
604842
3D Structure
ModBase 3D Structure for O75751
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human 41915. The exact sequence is proprietary.
Applications Tested/Suitable for anti-SLC22A3 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-SLC22A3 antibody
WB (1/500 - 1/1000), IP (1/10 - 1/100)

Western Blot (WB) of anti-SLC22A3 antibody

Western blot analysis of OCT3 expression in HT29 (A), JAR (B) whole cell lysates.
Rabbit Anti-SLC22A3 Polyclonal Antibody – Cat# MBS820928

Other Notes

Small volumes of anti-SLC22A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC22A3. It may not necessarily be applicable to this product.

NCBI GI #
11415038
NCBI GeneID
6581
NCBI Accession #
NP_068812.1
UniProt Primary Accession #
O75751
UniProt Secondary Accession #
Q5SYN6; Q9UP02
UniProt Related Accession #
O75751
GenBank Nucleotide #
NM_021977.3
NCBI Official Full Name
solute carrier family 22 member 3
NCBI Official Synonym Full Names
solute carrier family 22 (organic cation transporter), member 3
NCBI Official Symbol
SLC22A3
NCBI Official Synonym Symbols
EMT; EMTH; OCT3
UniProt Protein Name
Solute carrier family 22 member 3
UniProt Synonym Protein Names
Extraneuronal monoamine transporter; EMT; Organic cation transporter 3
Protein Family
Solute carrier family
UniProt Gene Name
SLC22A3
UniProt Synonym Gene Names
EMTH; OCT3; EMT
UniProt Entry Name
S22A3_HUMAN
NCBI Protein Information
solute carrier family 22 member 3; organic cation transporter 3; EMT organic cation transporter 3; extraneuronal monoamine transporter; solute carrier family 22 (extraneuronal monoamine transporter), member 3

NCBI Summary for SLC22A3

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for SLC22A3

SLC22A3: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; toxin transporter activity; organic cation transmembrane transporter activity; dopamine transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity

Biological Process: dopamine transport; quaternary ammonium group transport; organic cation transport; histamine uptake; regulation of appetite; multidrug transport; transmembrane transport
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Research Articles on SLC22A3

1. Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC22A3 antibody

 Reference Product  PubMed Publications
 IGF2R antibody  >9 publications with SLC22A3 and IGF2R
 LPAL2 antibody  >5 publications with SLC22A3 and LPAL2
 ABCG2 antibody  >1 publications with SLC22A3 and ABCG2
 ABCB1 antibody  >1 publications with SLC22A3 and ABCB1

Pathways associated with anti-SLC22A3 antibody

 Products by Pathway  Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Organic Cation Transport Pathway antibodies  Organic Cation Transport Pathway Diagram
 Organic Cation/anion/zwitterion Transport Pathway antibodies  Organic Cation/anion/zwitterion Transport Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC22A3 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >8 publications with SLC22A3 and Heart Diseases
 Prostatic Neoplasms Antibodies  >5 publications with SLC22A3 and Prostatic Neoplasms
 Myocardial Infarction Antibodies  >4 publications with SLC22A3 and Myocardial Infarction
 Kidney Diseases Antibodies  >4 publications with SLC22A3 and Kidney Diseases
 Anxiety Disorders Antibodies  >3 publications with SLC22A3 and Anxiety Disorders
 Hypertension Antibodies  >3 publications with SLC22A3 and Hypertension
 Inflammation Antibodies  >2 publications with SLC22A3 and Inflammation
 Substance-Related Disorders Antibodies  >2 publications with SLC22A3 and Substance-Related Disorders
 Muscular Diseases Antibodies  >1 publications with SLC22A3 and Muscular Diseases
 Heart Failure Antibodies  >1 publications with SLC22A3 and Heart Failure

Organs/Tissues associated with anti-SLC22A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >17 publications with SLC22A3 and Liver
 Kidney Antibodies  >15 publications with SLC22A3 and Kidney
 Brain Antibodies  >14 publications with SLC22A3 and Brain
 Placenta Antibodies  >11 publications with SLC22A3 and Placenta
 Muscle Antibodies  >9 publications with SLC22A3 and Muscle
 Embryonic Tissue Antibodies  >8 publications with SLC22A3 and Embryonic Tissue
 Prostate Antibodies  >8 publications with SLC22A3 and Prostate
 Intestine Antibodies  >6 publications with SLC22A3 and Intestine
 Vascular Antibodies  >4 publications with SLC22A3 and Vascular
 Lung Antibodies  >3 publications with SLC22A3 and Lung
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