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SLC24A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820936

MBS820936 is an antibody targeting SLC24A1. Also known as Anti-NCKX1 Antibody. Reactive in Human, Mouse, Monkey. Host: Rabbit. Rabbit polyclonal antibody to NCKX1 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NCKX1 (SLC24A1), Polyclonal Antibody
Full Product Name
Anti-NCKX1 Antibody
Product Gene Name
anti-SLC24A1 antibody
Product Synonym Names
KIAA0702; NCKX1; Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of NCKX1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
NCKX1 peptide (MBS824250) is used for blocking the activity of NCKX1 antibody (MBS820936)
Molecular Weight
117,632 Da
OMIM
gene 613830
3D Structure
ModBase 3D Structure for O60721
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NCKX1. The exact sequence is proprietary.
Applications Tested/Suitable for anti-SLC24A1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemsitry (ICC)
Application Notes for anti-SLC24A1 antibody
WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-SLC24A1 antibody

Western blot analysis of NCKX1 expression in HeLa (A), SP2/0 (B), NIH3T3 (C) whole cell lysates.
Rabbit Anti-SLC24A1 Polyclonal Antibody – Cat# MBS820936

Immunofluorescence (IF) of anti-SLC24A1 antibody

Immunofluorescent analysis of NCKX1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-SLC24A1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS820936

Other Notes

Small volumes of anti-SLC24A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC24A1. It may not necessarily be applicable to this product.

NCBI GI #
666335647
NCBI GeneID
9187
NCBI Accession #
NP_001287960.1
UniProt Primary Accession #
O60721
UniProt Secondary Accession #
O43485; O75184; Q17RM9
UniProt Related Accession #
O60721
GenBank Nucleotide #
NM_001301031.1
NCBI Official Full Name
sodium/potassium/calcium exchanger 1 isoform 3
NCBI Official Synonym Full Names
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
NCBI Official Symbol
SLC24A1
NCBI Official Synonym Symbols
NCKX; RODX; NCKX1; CSNB1D; HsT17412
UniProt Protein Name
Sodium/potassium/calcium exchanger 1
UniProt Synonym Protein Names
Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1
Protein Family
Sodium/potassium/calcium exchanger
UniProt Gene Name
SLC24A1
UniProt Synonym Gene Names
KIAA0702; NCKX1
UniProt Entry Name
NCKX1_HUMAN
NCBI Protein Information
sodium/potassium/calcium exchanger 1; retinal rod Na+/Ca+/K+ exchanger; solute carrier family 24 member 1; Na(+)/K(+)/Ca(2+)-exchange protein 1

NCBI Summary for SLC24A1

This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for SLC24A1

SLC24A1: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Defects in SLC24A1 are the cause of congenital stationary night blindness type 1D (CSNB1D). An autosomal recessive form of congenital stationary night blindness a non- progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus. Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: membrane; outer membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; calcium, potassium:sodium antiporter activity; symporter activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; visual perception; transport; calcium ion transport; response to light intensity; ion transport; transmembrane transport

Disease: Night Blindness, Congenital Stationary, Type 1d
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Research Articles on SLC24A1

1. A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC24A1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of The Phototransduction Cascade Pathway antibodies  Activation Of The Phototransduction Cascade Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Sodium/Calcium Exchangers Pathway antibodies  Sodium/Calcium Exchangers Pathway Diagram
 The Phototransduction Cascade Pathway antibodies  The Phototransduction Cascade Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Organs/Tissues associated with anti-SLC24A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with SLC24A1 and Eye
 Brain Antibodies  >1 publications with SLC24A1 and Brain
 Lung Antibodies  >1 publications with SLC24A1 and Lung
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