RTCA Antibody – Rabbit Polyclonal

This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

RTCD1: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.5.1.4; RNA-binding

Chromosomal Location of Human Ortholog: 1p21.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA binding; RNA-3'-phosphate cyclase activity; ATP binding

Biological Process: RNA processing