Collagen 5 Alpha 3 (COL5A3) Antibody – Rabbit Polyclonal

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]

COL5A3: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Belongs to the fibrillar collagen family.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: collagen type V; endoplasmic reticulum lumen; extracellular region

Molecular Function: heparin binding; collagen binding; proteoglycan binding; extracellular matrix structural constituent

Biological Process: skin development; extracellular matrix disassembly; axon guidance; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; cell-matrix adhesion