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TNFAIP8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821136

MBS821136 is an antibody targeting TNFAIP8. Also known as Anti-SCC-S2 Antibody. Reactive in Human, Mouse, Rat, Bovine, Chicken, Pig. Host: Rabbit. Rabbit polyclonal antibody to SCC-S2 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SCC-S2 (TNFAIP8), Polyclonal Antibody
Full Product Name
Anti-SCC-S2 Antibody
Product Gene Name
anti-TNFAIP8 antibody
Product Synonym Names
Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of SCC-S2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
SCC-S2 peptide (MBS824425) is used for blocking the activity of SCC-S2 antibody (MBS821136)
Molecular Weight
24,385 Da
OMIM
612111
3D Structure
ModBase 3D Structure for O95379
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SCC-S2. The exact sequence is proprietary.
Applications Tested/Suitable for anti-TNFAIP8 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-TNFAIP8 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-TNFAIP8 antibody

Western blot analysis of SCC-S2 expression in K562 (A), Raw264.7 (B) whole cell lysates.
Rabbit Anti-TNFAIP8 Polyclonal Antibody – Cat# MBS821136

Immunohistochemistry (IHC) of anti-TNFAIP8 antibody

Immunohistochemical analysis of SCC-S2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-TNFAIP8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821136

Immunofluorescence (IF) of anti-TNFAIP8 antibody

Immunofluorescent analysis of SCC-S2 staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-TNFAIP8 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS821136

Other Notes

Small volumes of anti-TNFAIP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFAIP8. It may not necessarily be applicable to this product.

NCBI GI #
117676370
NCBI GeneID
25816
NCBI Accession #
NP_001071122.1
UniProt Primary Accession #
O95379
UniProt Secondary Accession #
Q9P1Q1; Q9UER5; Q9UP47; B3KMH1; B3KMI2; B7Z713
UniProt Related Accession #
O95379
GenBank Nucleotide #
NM_001077654.2
NCBI Official Full Name
tumor necrosis factor alpha-induced protein 8 isoform b
NCBI Official Synonym Full Names
tumor necrosis factor, alpha-induced protein 8
NCBI Official Symbol
TNFAIP8
NCBI Official Synonym Symbols
NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13
UniProt Protein Name
Tumor necrosis factor alpha-induced protein 8
UniProt Synonym Protein Names
Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1
Protein Family
Tumor necrosis factor alpha-induced protein
UniProt Gene Name
TNFAIP8
UniProt Synonym Gene Names
TNF alpha-induced protein 8; NDED
UniProt Entry Name
TFIP8_HUMAN
NCBI Protein Information
tumor necrosis factor alpha-induced protein 8; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein

UniProt Comments for TNFAIP8

TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: cytoplasm

Molecular Function: caspase inhibitor activity

Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of caspase activity; negative regulation of apoptosis
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Research Articles on TNFAIP8

1. TNFAIP8 may be used as a prognostic marker for the recurrence of endometrial cancer (EC), and its promotion of the proliferation and metastasis in EC may be due to its mediation of Ki-67 and MMP9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFAIP8 antibody

 Reference Product  PubMed Publications
 TNF antibody  >8 publications with TNFAIP8 and TNF

Diseases associated with anti-TNFAIP8 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >24 publications with TNFAIP8 and Necrosis
 Inflammation Antibodies  >7 publications with TNFAIP8 and Inflammation
 Neoplasm Metastasis Antibodies  >5 publications with TNFAIP8 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >3 publications with TNFAIP8 and Disease Models, Animal
 Prostatic Diseases Antibodies  >2 publications with TNFAIP8 and Prostatic Diseases
 Lung Neoplasms Antibodies  >2 publications with TNFAIP8 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with TNFAIP8 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >2 publications with TNFAIP8 and Adenocarcinoma
 Nervous System Diseases Antibodies  >2 publications with TNFAIP8 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with TNFAIP8 and Cardiovascular Diseases

Organs/Tissues associated with anti-TNFAIP8 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with TNFAIP8 and Lung
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