Rabbit Anti-CHRNA5 Polyclonal Antibody – Cat# MBS821143

Western blot analysis of CHRNA5 expression in HeLa (A), Jurkat (B), mouse brain (C), rat brain (D) whole cell lysates.

CHRNA5 Antibody – Rabbit Polyclonal

Name: CHRNA5 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS821143
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821143

MBS821143 is an antibody targeting CHRNA5. Reactive in Human, Mouse, Rat, Bovine, Chicken, Monkey. Host: Rabbit. Rabbit polyclonal antibody to CHRNA5 More details

$225 / 0.03 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CHRNA5, Polyclonal Antibody

Full Product Name

Anti-CHRNA5 Antibody

Product Gene Name

anti-CHRNA5 antibody

Product Synonym Names

NACHRA5; Neuronal acetylcholine receptor subunit alpha-5

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Bovine, Chicken, Monkey

Form/Format

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purity/Purification

The antibody was purified by immunogen affinity chromatography.

Specificity

Recognizes endogenous levels of CHRNA5 protein.

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Antibody/Peptide Pairs

CHRNA5 peptide (MBS823168) is used for blocking the activity of CHRNA5 antibody (MBS821143)

Molecular Weight

53,054 Da

OMIM

gene 612052

3D Structure

ModBase 3D Structure for P30532

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CHRNA5. The exact sequence is proprietary.

Applications Tested/Suitable for anti-CHRNA5 antibody

Western Blot (WB)

Application Notes for anti-CHRNA5 antibody

WB (1/500 - 1/1000)

Other Notes

Small volumes of anti-CHRNA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRNA5. It may not necessarily be applicable to this product.

NCBI GI #

33589827

NCBI GeneID

1138

NCBI Accession #

NP_000736.2

UniProt Primary Accession #

P30532

UniProt Secondary Accession #

Q15824; Q99554

UniProt Related Accession #

P30532

GenBank Nucleotide #

NM_000745.3

NCBI Official Full Name

neuronal acetylcholine receptor subunit alpha-5

NCBI Official Synonym Full Names

cholinergic receptor, nicotinic, alpha 5 (neuronal)

NCBI Official Symbol

CHRNA5

NCBI Official Synonym Symbols

LNCR2

UniProt Protein Name

Neuronal acetylcholine receptor subunit alpha-5

Protein Family

Neuronal acetylcholine receptor

UniProt Gene Name

CHRNA5

UniProt Synonym Gene Names

NACHRA5

UniProt Entry Name

ACHA5_HUMAN

NCBI Protein Information

neuronal acetylcholine receptor subunit alpha-5; acetylcholine receptor, nicotinic, alpha 5 (neuronal); neuronal nicotinic acetylcholine receptor, alpha5 subunit; Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5

NCBI Summary for CHRNA5

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

UniProt Comments for CHRNA5

nAChRA5: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction

Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; behavioral response to nicotine; signal transduction; cation transport

Disease: Smoking As A Quantitative Trait Locus 3

Research Articles on CHRNA5

1. substance dependence associated variants have a direct cis-regulatory effect on CHRNA5 transcript levels in human frontal cortices of African and European ancestry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHRNA5 antibody

Reference Product	PubMed Publications
CHRNA3 antibody	>130 publications with CHRNA5 and CHRNA3
CHRNB4 antibody	>103 publications with CHRNA5 and CHRNB4
CHRNA4 antibody	>16 publications with CHRNA5 and CHRNA4
CHRNA7 antibody	>14 publications with CHRNA5 and CHRNA7
CHRNA6 antibody	>13 publications with CHRNA5 and CHRNA6
CHRNB2 antibody	>13 publications with CHRNA5 and CHRNB2
PSMA4 antibody	>7 publications with CHRNA5 and PSMA4
CHRNA2 antibody	>6 publications with CHRNA5 and CHRNA2
CHRNB1 antibody	>4 publications with CHRNA5 and CHRNB1
AGPHD1 antibody	>2 publications with CHRNA5 and AGPHD1

Pathways associated with anti-CHRNA5 antibody

Products by Pathway	Pathway Diagram
Acetylcholine Binding And Downstream Events Pathway antibodies	Acetylcholine Binding And Downstream Events Pathway Diagram
Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies	Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies	Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies	Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Nicotine Activity On Dopaminergic Neurons Pathway antibodies	Nicotine Activity On Dopaminergic Neurons Pathway Diagram
Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies	Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram

Diseases associated with anti-CHRNA5 antibody

Disease Name	Pubmed Publications
Substance-Related Disorders Antibodies	>91 publications with CHRNA5 and Substance-Related Disorders
Tobacco Use Disorder Antibodies	>82 publications with CHRNA5 and Tobacco Use Disorder
Lung Neoplasms Antibodies	>54 publications with CHRNA5 and Lung Neoplasms
Brain Diseases Antibodies	>18 publications with CHRNA5 and Brain Diseases
TOBACCO ADDICTION, SUSCEPTIBILITY TO Antibodies	>17 publications with CHRNA5 and TOBACCO ADDICTION, SUSCEPTIBILITY TO
Nervous System Diseases Antibodies	>16 publications with CHRNA5 and Nervous System Diseases
Alcoholism Antibodies	>11 publications with CHRNA5 and Alcoholism
Cocaine-Related Disorders Antibodies	>8 publications with CHRNA5 and Cocaine-Related Disorders
Seizures Antibodies	>5 publications with CHRNA5 and Seizures
Pain Antibodies	>4 publications with CHRNA5 and Pain

Organs/Tissues associated with anti-CHRNA5 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>140 publications with CHRNA5 and Nerve
Lung Antibodies	>87 publications with CHRNA5 and Lung
Brain Antibodies	>49 publications with CHRNA5 and Brain
Mixed Antibodies	>3 publications with CHRNA5 and Mixed
Bladder Antibodies	>2 publications with CHRNA5 and Bladder
Kidney Antibodies	>2 publications with CHRNA5 and Kidney
Embryonic Tissue Antibodies	>2 publications with CHRNA5 and Embryonic Tissue
Pancreas Antibodies	>1 publications with CHRNA5 and Pancreas
Mouth Antibodies	>1 publications with CHRNA5 and Mouth
Stomach Antibodies	>1 publications with CHRNA5 and Stomach