• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

UBR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821266

MBS821266 is an antibody targeting UBR2. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to UBR2 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UBR2, Polyclonal Antibody
Full Product Name
Anti-UBR2 Antibody
Product Gene Name
anti-UBR2 antibody
Product Synonym Names
C6orf133; KIAA0349; E3 ubiquitin-protein ligase UBR2; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of UBR2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
UBR2 peptide (MBS824196) is used for blocking the activity of UBR2 antibody (MBS821266)
Molecular Weight
200,540 Da
OMIM
609134
3D Structure
ModBase 3D Structure for Q8IWV8
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human UBR2. The exact sequence is proprietary.
Applications Tested/Suitable for anti-UBR2 antibody
Western Blot (WB)
Application Notes for anti-UBR2 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-UBR2 antibody

Western blot analysis of UBR2 expression in HepG2 (A), mouse liver (B), rat liver (C) whole cell lysates.
Rabbit Anti-UBR2 Polyclonal Antibody – Cat# MBS821266

Other Notes

Small volumes of anti-UBR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UBR2. It may not necessarily be applicable to this product.

NCBI GI #
296317280
NCBI GeneID
23304
NCBI Accession #
NP_001171730.1
UniProt Primary Accession #
Q8IWV8
UniProt Secondary Accession #
O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0
UniProt Related Accession #
Q8IWV8
GenBank Nucleotide #
NM_001184801.1
NCBI Official Full Name
E3 ubiquitin-protein ligase UBR2 isoform 2
NCBI Official Synonym Full Names
ubiquitin protein ligase E3 component n-recognin 2
NCBI Official Symbol
UBR2
NCBI Official Synonym Symbols
C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3
UniProt Protein Name
E3 ubiquitin-protein ligase UBR2
UniProt Synonym Protein Names
N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
UBR2
UniProt Synonym Gene Names
C6orf133; KIAA0349
UniProt Entry Name
UBR2_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase UBR2; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II

NCBI Summary for UBR2

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UniProt Comments for UBR2

UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; plasma membrane; chromatin; ubiquitin ligase complex

Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; spermatogenesis; histone H2A ubiquitination
Show more

Research Articles on UBR2

1. The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBR2 antibody

 Reference Product  PubMed Publications
 UBR4 antibody  >7 publications with UBR2 and UBR4
 UBE2B antibody  >2 publications with UBR2 and UBE2B
 RECQL4 antibody  >1 publications with UBR2 and RECQL4

Pathways associated with anti-UBR2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-UBR2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with UBR2 and Nervous System Diseases
 Genital Diseases, Male Antibodies  >2 publications with UBR2 and Genital Diseases, Male
 Infertility, Female Antibodies  >1 publications with UBR2 and Infertility, Female
 Cardiovascular Diseases Antibodies  >1 publications with UBR2 and Cardiovascular Diseases
 Hypertrophy Antibodies  >1 publications with UBR2 and Hypertrophy

Organs/Tissues associated with anti-UBR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >5 publications with UBR2 and Muscle
 Testis Antibodies  >4 publications with UBR2 and Testis
 Blood Antibodies  >3 publications with UBR2 and Blood
 Lung Antibodies  >2 publications with UBR2 and Lung
 Heart Antibodies  >2 publications with UBR2 and Heart
 Pancreas Antibodies  >1 publications with UBR2 and Pancreas
 Vascular Antibodies  >1 publications with UBR2 and Vascular
 Eye Antibodies  >1 publications with UBR2 and Eye
 Embryonic Tissue Antibodies  >1 publications with UBR2 and Embryonic Tissue
 Bone Antibodies  >1 publications with UBR2 and Bone
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000