PFKFB2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described.

Protein type: Carbohydrate Metabolism - fructose and mannose; Motility/polarity/chemotaxis; EC 3.1.3.46; Phosphatase (non-protein); EC 2.7.1.105; Kinase, other

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytosol

Molecular Function: protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; protein kinase binding; ATP binding

Biological Process: glycolysis; positive regulation of insulin secretion; glucose metabolic process; pathogenesis; fructose 2,6-bisphosphate metabolic process; glucose catabolic process; dephosphorylation; carbohydrate metabolic process; lactate metabolic process; carbohydrate phosphorylation; response to glucose stimulus; positive regulation of glucokinase activity; fructose metabolic process