XRCC2 Antibody – Rabbit Polyclonal

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

XRCC2: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Belongs to the RecA family. RAD51 subfamily.

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: centrosome; cytoplasm; replication fork

Molecular Function: DNA-dependent ATPase activity; protein binding; four-way junction DNA binding; ATP binding

Biological Process: meiosis; positive regulation of neurogenesis; somitogenesis; centrosome organization and biogenesis; in utero embryonic development; multicellular organism growth; response to gamma radiation; strand invasion; mitotic cell cycle; negative regulation of neuron apoptosis; DNA repair; double-strand break repair via homologous recombination; response to X-ray