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DAB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821378

MBS821378 is an antibody targeting DAB1. Reactive in Human, Mouse, Rat, Chicken, Monkey, Pig. Host: Rabbit. Rabbit polyclonal antibody to DAB1 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DAB1, Polyclonal Antibody
Full Product Name
Anti-DAB1 Antibody
Product Gene Name
anti-DAB1 antibody
Product Synonym Names
Disabled homolog 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Chicken, Monkey, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of DAB1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
DAB1 peptide (MBS824324) is used for blocking the activity of DAB1 antibody (MBS821378)
Molecular Weight
59,900 Da
3D Structure
ModBase 3D Structure for O75553
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DAB1. The exact sequence is proprietary.
Applications Tested/Suitable for anti-DAB1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemsitry (ICC)
Application Notes for anti-DAB1 antibody
WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-DAB1 antibody

Western blot analysis of DAB1 expression in MCF7 (A), HEK293T (B) whole cell lysates.
Rabbit Anti-DAB1 Polyclonal Antibody – Cat# MBS821378

Immunofluorescence (IF) of anti-DAB1 antibody

Immunofluorescent analysis of DAB1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-DAB1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS821378

Other Notes

Small volumes of anti-DAB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DAB1. It may not necessarily be applicable to this product.

NCBI GI #
33350928
NCBI GeneID
1600
NCBI Accession #
NP_066566.3
UniProt Primary Accession #
O75553
UniProt Secondary Accession #
P97318; Q8CJH2
UniProt Related Accession #
O75553
GenBank Nucleotide #
NM_021080.3
NCBI Official Full Name
disabled homolog 1
NCBI Official Synonym Full Names
Dab, reelin signal transducer, homolog 1 (Drosophila)
NCBI Official Symbol
DAB1
UniProt Protein Name
Disabled homolog 1
Protein Family
Disabled
UniProt Gene Name
Dab1
UniProt Entry Name
DAB1_RAT
NCBI Protein Information
disabled homolog 1; Dab reelin signal transducer 1

NCBI Summary for DAB1

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for DAB1

DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: neuron projection; cell soma; membrane; apical part of cell; perinuclear region of cytoplasm; postsynaptic density; cytosol; brush border

Molecular Function: phosphoinositide 3-kinase binding

Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; response to drug; Golgi localization; cerebellum structural organization; ventral spinal cord development; negative regulation of cell adhesion; adult walking behavior; positive regulation of protein kinase activity; small GTPase mediated signal transduction; radial glia guided migration of Purkinje cell; negative regulation of astrocyte differentiation; dendrite development; midgut development; cerebral cortex radially oriented cell migration; negative regulation of axonogenesis; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
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Research Articles on DAB1

1. The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DAB1 antibody

 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram

Diseases associated with anti-DAB1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >36 publications with DAB1 and Nervous System Diseases
 Movement Disorders Antibodies  >11 publications with DAB1 and Movement Disorders
 Disease Models, Animal Antibodies  >6 publications with DAB1 and Disease Models, Animal
 Pain Antibodies  >3 publications with DAB1 and Pain
 Inflammation Antibodies  >2 publications with DAB1 and Inflammation
 Mood Disorders Antibodies  >2 publications with DAB1 and Mood Disorders
 Nerve Degeneration Antibodies  >2 publications with DAB1 and Nerve Degeneration
 Abnormalities, Drug-Induced Antibodies  >2 publications with DAB1 and Abnormalities, Drug-Induced
 Autistic Disorder Antibodies  >2 publications with DAB1 and Autistic Disorder
 Memory Disorders Antibodies  >1 publications with DAB1 and Memory Disorders

Organs/Tissues associated with anti-DAB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >250 publications with DAB1 and Brain
 Embryonic Tissue Antibodies  >80 publications with DAB1 and Embryonic Tissue
 Eye Antibodies  >15 publications with DAB1 and Eye
 Liver Antibodies  >7 publications with DAB1 and Liver
 Kidney Antibodies  >6 publications with DAB1 and Kidney
 Lung Antibodies  >2 publications with DAB1 and Lung
 Testis Antibodies  >1 publications with DAB1 and Testis
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