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TRIP13 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821393

MBS821393 is an antibody targeting TRIP13. Reactive in Human, Mouse, Rat, Dog. Host: Rabbit. Rabbit polyclonal antibody to TRIP13 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRIP13, Polyclonal Antibody
Full Product Name
Anti-TRIP13 Antibody
Product Gene Name
anti-TRIP13 antibody
Product Synonym Names
PCH2; Pachytene checkpoint protein 2 homolog; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of TRIP13 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
TRIP13 peptide (MBS824365) is used for blocking the activity of TRIP13 antibody (MBS821393)
Molecular Weight
22,084 Da
OMIM
604507
3D Structure
ModBase 3D Structure for Q15645
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TRIP13. The exact sequence is proprietary.
Applications Tested/Suitable for anti-TRIP13 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TRIP13 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-TRIP13 antibody

Western blot analysis of TRIP13 expression in Jurkat (A), NIH3T3 (B), PC12 (C) whole cell lysates.
Rabbit Anti-TRIP13 Polyclonal Antibody – Cat# MBS821393

Immunohistochemistry (IHC) of anti-TRIP13 antibody

Immunohistochemical analysis of TRIP13 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-TRIP13 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821393

Other Notes

Small volumes of anti-TRIP13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIP13. It may not necessarily be applicable to this product.

NCBI GI #
11321607
NCBI GeneID
9319
NCBI Accession #
NP_004228.1
UniProt Primary Accession #
Q15645
UniProt Secondary Accession #
O15324; C9K0T3; D3DTC0
UniProt Related Accession #
Q15645
GenBank Nucleotide #
NM_004237.3
NCBI Official Full Name
pachytene checkpoint protein 2 homolog isoform 1
NCBI Official Synonym Full Names
thyroid hormone receptor interactor 13
NCBI Official Symbol
TRIP13
NCBI Official Synonym Symbols
16E1BP
UniProt Protein Name
Pachytene checkpoint protein 2 homolog
UniProt Synonym Protein Names
Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13
UniProt Gene Name
TRIP13
UniProt Synonym Gene Names
PCH2; 16E1-BP; HPV16 E1 protein-binding protein; TR-interacting protein 13; TRIP-13
UniProt Entry Name
PCH2_HUMAN
NCBI Protein Information
pachytene checkpoint protein 2 homolog; 16E1-BP; TRIP-13; TR-interacting protein 13; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; thyroid receptor interacting protein 13; thyroid receptor-interacting protein 13; human papillomavirus type 16 E1 protein-binding protein

NCBI Summary for TRIP13

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
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UniProt Comments for TRIP13

TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: male germ cell nucleus; nucleus

Molecular Function: identical protein binding; protein binding; transcription cofactor activity; ATP binding

Biological Process: oogenesis; transcription from RNA polymerase II promoter; synaptonemal complex assembly; male meiosis I; double-strand break repair; meiotic recombination; spermatogenesis; oocyte maturation; spermatid development; female meiosis I
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Research Articles on TRIP13

1. propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIP13 antibody

 Reference Product  PubMed Publications
 MAD2L1 antibody  >1 publications with TRIP13 and MAD2L1

Diseases associated with anti-TRIP13 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >1 publications with TRIP13 and Carcinoma, Squamous Cell
 Prostatic Neoplasms Antibodies  >1 publications with TRIP13 and Prostatic Neoplasms
 Infertility, Male Antibodies  >1 publications with TRIP13 and Infertility, Male
 Lung Neoplasms Antibodies  >1 publications with TRIP13 and Lung Neoplasms
 Infertility, Female Antibodies  >1 publications with TRIP13 and Infertility, Female

Organs/Tissues associated with anti-TRIP13 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with TRIP13 and Skin
 Prostate Antibodies  >1 publications with TRIP13 and Prostate
 Lung Antibodies  >1 publications with TRIP13 and Lung
 Ovary Antibodies  >1 publications with TRIP13 and Ovary
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