Histone Deacetylase 5 (Ps498) (HDAC5) Antibody – Rabbit Polyclonal

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDAC5: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described.

Protein type: Hydrolase; EC 3.5.1.98

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; Golgi apparatus; nuclear body; histone deacetylase complex; cytoplasm; cytosol; nucleus

Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; metal ion binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding; transcription corepressor activity

Biological Process: response to drug; regulation of skeletal muscle fiber development; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; B cell activation; transcription, DNA-dependent; heart development; chromatin silencing; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; response to cocaine; regulation of gene expression, epigenetic; osteoblast development; chromatin remodeling; protein amino acid deacetylation; cellular response to insulin stimulus; B cell differentiation; regulation of protein binding; negative regulation of osteoblast differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inflammatory response; multicellular organismal response to stress