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KCNMB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821443

MBS821443 is an antibody targeting KCNMB2. Reactive in Human, Mouse, Rat, Bovine. Host: Rabbit. Rabbit polyclonal antibody to KCNMB2 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KCNMB2, Polyclonal Antibody
Full Product Name
Anti-KCNMB2 Antibody
Product Gene Name
anti-KCNMB2 antibody
Product Synonym Names
Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of KCNMB2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
KCNMB2 peptide (MBS823772) is used for blocking the activity of KCNMB2 antibody (MBS821443)
Molecular Weight
27,130 Da
OMIM
605214
3D Structure
ModBase 3D Structure for Q9Y691
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human KCNMB2. The exact sequence is proprietary.
Applications Tested/Suitable for anti-KCNMB2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-KCNMB2 antibody
WB (1/500 - 1/1000), IP (1/10 - 1/100)

Western Blot (WB) of anti-KCNMB2 antibody

Western blot analysis of KCNMB2 expression in HepG2 (A) whole cell lysates.
Rabbit Anti-KCNMB2 Polyclonal Antibody – Cat# MBS821443

Immunohistochemistry (IHC) of anti-KCNMB2 antibody

Rabbit Anti-KCNMB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821443

Other Notes

Small volumes of anti-KCNMB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNMB2. It may not necessarily be applicable to this product.

NCBI GI #
524589096
NCBI GeneID
10242
NCBI Accession #
NP_001265840.1
UniProt Primary Accession #
Q9Y691
UniProt Secondary Accession #
Q9CZM9; Q811Q0
UniProt Related Accession #
Q9Y691
GenBank Nucleotide #
NM_001278911.1
NCBI Official Full Name
calcium-activated potassium channel subunit beta-2
NCBI Official Synonym Full Names
potassium large conductance calcium-activated channel, subfamily M, beta member 2
NCBI Official Symbol
KCNMB2
UniProt Protein Name
Calcium-activated potassium channel subunit beta-2
UniProt Synonym Protein Names
BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
Protein Family
Calcium-activated potassium channel
UniProt Gene Name
KCNMB2
UniProt Synonym Gene Names
BKbeta2; Hbeta2
UniProt Entry Name
KCMB2_HUMAN
NCBI Protein Information
calcium-activated potassium channel subunit beta-2; hbeta2; hCG1646471; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; MaxiK channel beta 2 subunit; charybdotoxin receptor subunit beta-2; large-conductance Ca2+-activated K+ channel beta2 subunit; large conductance calcium-activated potassium channel beta 2 subunit

NCBI Summary for KCNMB2

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
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UniProt Comments for KCNMB2

KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q26.32

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; ion channel inhibitor activity

Biological Process: synaptic transmission; regulation of action potential; regulation of vasoconstriction; generation of action potential; detection of calcium ion; blood coagulation; potassium ion transport
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Research Articles on KCNMB2

1. IFN-gamma changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KCNMB2 antibody

 Products by Pathway  Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 CGMP Effects Pathway antibodies  CGMP Effects Pathway Diagram

Diseases associated with anti-KCNMB2 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1 publications with KCNMB2 and Fibrosis

Organs/Tissues associated with anti-KCNMB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with KCNMB2 and Lung
 Nerve Antibodies  >1 publications with KCNMB2 and Nerve
 Kidney Antibodies  >1 publications with KCNMB2 and Kidney
 Brain Antibodies  >1 publications with KCNMB2 and Brain
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