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ARHGEF10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821461

MBS821461 is an antibody targeting ARHGEF10. Reactive in Human, Mouse. Host: Rabbit. Rabbit polyclonal antibody to ARHGEF10 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARHGEF10, Polyclonal Antibody
Full Product Name
Anti-ARHGEF10 Antibody
Product Gene Name
anti-ARHGEF10 antibody
Product Synonym Names
KIAA0294; Rho guanine nucleotide exchange factor 10
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of ARHGEF10 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
ARHGEF10 peptide (MBS822584) is used for blocking the activity of ARHGEF10 antibody (MBS821461)
Molecular Weight
148,869 Da
OMIM
gene 608236
3D Structure
ModBase 3D Structure for O15013
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ARHGEF10. The exact sequence is proprietary.
Applications Tested/Suitable for anti-ARHGEF10 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ARHGEF10 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-ARHGEF10 antibody

Western blot analysis of ARHGEF10 expression in HeLa (A), HEK293T (B), SP2/0 (C) whole cell lysates.
Rabbit Anti-ARHGEF10 Polyclonal Antibody – Cat# MBS821461

Immunohistochemistry (IHC) of anti-ARHGEF10 antibody

Immunohistochemical analysis of ARHGEF10 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-ARHGEF10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821461

Other Notes

Small volumes of anti-ARHGEF10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF10. It may not necessarily be applicable to this product.

NCBI GI #
62548864
NCBI GeneID
9639
NCBI Accession #
NP_055444.2
UniProt Primary Accession #
O15013
UniProt Secondary Accession #
O14665; Q2KHR8; Q68D55; Q8IWD9; Q8IY77
UniProt Related Accession #
O15013
GenBank Nucleotide #
NM_014629.2
NCBI Official Full Name
rho guanine nucleotide exchange factor 10
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF) 10
NCBI Official Symbol
ARHGEF10
NCBI Official Synonym Symbols
SNCV; GEF10
UniProt Protein Name
Rho guanine nucleotide exchange factor 10
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF10
UniProt Synonym Gene Names
KIAA0294
UniProt Entry Name
ARHGA_HUMAN
NCBI Protein Information
rho guanine nucleotide exchange factor 10

NCBI Summary for ARHGEF10

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]

UniProt Comments for ARHGEF10

ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: centrosome; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; kinesin binding

Biological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous system

Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant
Show more

Research Articles on ARHGEF10

1. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARHGEF10 antibody

 Reference Product  PubMed Publications
 KIF3B antibody  >1 publications with ARHGEF10 and KIF3B

Pathways associated with anti-ARHGEF10 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram

Diseases associated with anti-ARHGEF10 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with ARHGEF10 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with ARHGEF10 and Brain Diseases
 Male Urogenital Diseases Antibodies  >1 publications with ARHGEF10 and Male Urogenital Diseases
 Liver Neoplasms Antibodies  >1 publications with ARHGEF10 and Liver Neoplasms
 Urinary Bladder Neoplasms Antibodies  >1 publications with ARHGEF10 and Urinary Bladder Neoplasms
 Atrophy Antibodies  >1 publications with ARHGEF10 and Atrophy
 Liver Diseases Antibodies  >1 publications with ARHGEF10 and Liver Diseases

Organs/Tissues associated with anti-ARHGEF10 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >5 publications with ARHGEF10 and Nerve
 Brain Antibodies  >3 publications with ARHGEF10 and Brain
 Muscle Antibodies  >2 publications with ARHGEF10 and Muscle
 Liver Antibodies  >1 publications with ARHGEF10 and Liver
 Pancreas Antibodies  >1 publications with ARHGEF10 and Pancreas
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