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COPS7A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821523

MBS821523 is an antibody targeting COPS7A. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit. Rabbit polyclonal antibody to COPS7A More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COPS7A, Polyclonal Antibody
Full Product Name
Anti-COPS7A Antibody
Product Gene Name
anti-COPS7A antibody
Product Synonym Names
CSN7A; DERP10; COP9 signalosome complex subunit 7a; SGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of COPS7A protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
COPS7A peptide (MBS822838) is used for blocking the activity of COPS7A antibody (MBS821523)
Molecular Weight
30,277 Da
OMIM
616009
3D Structure
ModBase 3D Structure for Q9UBW8
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human COPS7A. The exact sequence is proprietary.
Applications Tested/Suitable for anti-COPS7A antibody
Western Blot (WB)
Application Notes for anti-COPS7A antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-COPS7A antibody

Western blot analysis of COPS7A expression in JAR (A), HeLa (B), Raw264.7 (C), PC12 (D) whole cell lysates.
Rabbit Anti-COPS7A Polyclonal Antibody – Cat# MBS821523

Other Notes

Small volumes of anti-COPS7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COPS7A. It may not necessarily be applicable to this product.

NCBI GI #
255760064
NCBI GeneID
50813
NCBI Accession #
NP_001157565.1
UniProt Primary Accession #
Q9UBW8
UniProt Secondary Accession #
Q9NVX3; Q9UJW4; A8K9A6
UniProt Related Accession #
Q9UBW8
GenBank Nucleotide #
NM_001164093.1
NCBI Official Full Name
COP9 signalosome complex subunit 7a
NCBI Official Synonym Full Names
COP9 signalosome subunit 7A
NCBI Official Symbol
COPS7A
NCBI Official Synonym Symbols
CSN7; CSN7A; SGN7a
UniProt Protein Name
COP9 signalosome complex subunit 7a
UniProt Synonym Protein Names
Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a
UniProt Gene Name
COPS7A
UniProt Synonym Gene Names
CSN7A; DERP10; SGN7a; Signalosome subunit 7a
UniProt Entry Name
CSN7A_HUMAN
NCBI Protein Information
COP9 signalosome complex subunit 7a; COP9 complex subunit 7a; dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A

NCBI Summary for COPS7A

This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

UniProt Comments for COPS7A

COPS7A: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: signalosome; nucleoplasm; cytoplasm

Biological Process: cullin deneddylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COPS7A antibody

 Reference Product  PubMed Publications
 COPS5 antibody  >1 publications with COPS7A and COPS5
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