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CDC37 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821553

MBS821553 is an antibody targeting CDC37. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit. Rabbit polyclonal antibody to CDC37 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDC37, Polyclonal Antibody
Full Product Name
Anti-CDC37 Antibody
Product Gene Name
anti-CDC37 antibody
Product Synonym Names
CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of CDC37 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
CDC37 peptide (MBS823253) is used for blocking the activity of CDC37 antibody (MBS821553)
Molecular Weight
44,468 Da
OMIM
605065
3D Structure
ModBase 3D Structure for Q16543
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CDC37. The exact sequence is proprietary.
Applications Tested/Suitable for anti-CDC37 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-CDC37 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500), IP (1/10 - 1/100)

Western Blot (WB) of anti-CDC37 antibody

Western blot analysis of CDC37 expression in Jurkat (A), K562 (B), HL60 (C), NIH3T3 (D) whole cell lysates.
Rabbit Anti-CDC37 Polyclonal Antibody – Cat# MBS821553

Immunohistochemistry (IHC) of anti-CDC37 antibody

Immunohistochemical analysis of CDC37 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-CDC37 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821553

Immunofluorescence (IF) of anti-CDC37 antibody

Immunofluorescent analysis of CDC37 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-CDC37 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS821553

Other Notes

Small volumes of anti-CDC37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC37. It may not necessarily be applicable to this product.

NCBI GI #
5901922
NCBI GeneID
11140
NCBI Accession #
NP_008996.1
UniProt Primary Accession #
Q16543
UniProt Secondary Accession #
Q53YA2
UniProt Related Accession #
Q16543
GenBank Nucleotide #
NM_007065.3
NCBI Official Full Name
hsp90 co-chaperone Cdc37
NCBI Official Synonym Full Names
cell division cycle 37
NCBI Official Symbol
CDC37
NCBI Official Synonym Symbols
P50CDC37
UniProt Protein Name
Hsp90 co-chaperone Cdc37
UniProt Synonym Protein Names
Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37Cleaved into the following chain:Hsp90 co-chaperone Cdc37, N-terminally processed
Protein Family
Hsp90 co-chaperone
UniProt Gene Name
CDC37
UniProt Synonym Gene Names
CDC37A
UniProt Entry Name
CDC37_HUMAN
NCBI Protein Information
hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog)

NCBI Summary for CDC37

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
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UniProt Comments for CDC37

CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function: protein kinase B binding; protein binding; chaperone binding; heat shock protein binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding

Biological Process: protein stabilization; protein folding; regulation of cyclin-dependent protein kinase activity; protein targeting
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Research Articles on CDC37

1. CDC37 is a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDC37 antibody

 Reference Product  PubMed Publications
 CDK4 antibody  >31 publications with CDC37 and CDK4
 SRC antibody  >27 publications with CDC37 and SRC
 ERBB2 antibody  >7 publications with CDC37 and ERBB2
 IKBKB antibody  >4 publications with CDC37 and IKBKB
 STK11 antibody  >3 publications with CDC37 and STK11
 CHUK antibody  >2 publications with CDC37 and CHUK
 HSP90AA1 antibody  >1 publications with CDC37 and HSP90AA1

Pathways associated with anti-CDC37 antibody

 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By EGFR In Cancer Pathway antibodies  Signaling By EGFR In Cancer Pathway Diagram
 Signaling By ERBB2 Pathway antibodies  Signaling By ERBB2 Pathway Diagram
 Signaling By Constitutively Active EGFR Pathway antibodies  Signaling By Constitutively Active EGFR Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-CDC37 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >10 publications with CDC37 and Necrosis
 Gastrointestinal Diseases Antibodies  >7 publications with CDC37 and Gastrointestinal Diseases
 Pancreatic Neoplasms Antibodies  >6 publications with CDC37 and Pancreatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >6 publications with CDC37 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >6 publications with CDC37 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with CDC37 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >5 publications with CDC37 and Neoplasms, Experimental
 Inflammation Antibodies  >5 publications with CDC37 and Inflammation
 Breast Neoplasms Antibodies  >5 publications with CDC37 and Breast Neoplasms
 Liver Neoplasms, Experimental Antibodies  >3 publications with CDC37 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-CDC37 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with CDC37 and Blood
 Brain Antibodies  >10 publications with CDC37 and Brain
 Liver Antibodies  >9 publications with CDC37 and Liver
 Muscle Antibodies  >8 publications with CDC37 and Muscle
 Lung Antibodies  >7 publications with CDC37 and Lung
 Prostate Antibodies  >6 publications with CDC37 and Prostate
 Bone Antibodies  >6 publications with CDC37 and Bone
 Embryonic Tissue Antibodies  >5 publications with CDC37 and Embryonic Tissue
 Heart Antibodies  >4 publications with CDC37 and Heart
 Kidney Antibodies  >4 publications with CDC37 and Kidney
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