MYO3B Antibody – Rabbit Polyclonal

This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

MYO3B: an actin-based motor protein with protein kinase activity. A member of the myosin superfamily. Has a kinase domain of the STE20 family N-terminal to the conserved N-terminal motor domain. Expressed in retina, kidney and testis. Six alternatively spliced human isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Actin-binding; Kinase, protein; Motor; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; NinaC subfamily

Chromosomal Location of Human Ortholog: 2q31.1-q31.2

Cellular Component: filopodium tip; photoreceptor outer segment; photoreceptor inner segment; cytoplasm; stereocilium bundle tip; myosin complex

Molecular Function: microfilament motor activity; protein serine/threonine kinase activity; actin binding; ATP binding

Biological Process: positive regulation of filopodium formation; peptidyl-serine phosphorylation; visual perception; protein amino acid autophosphorylation; response to stimulus; peptidyl-threonine phosphorylation