KCNC1 Antibody – Rabbit Polyclonal

This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Kv3.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; cell surface; membrane; cell soma; dendrite; integral to membrane; axolemma

Molecular Function: voltage-gated potassium channel activity; potassium channel activity; kinesin binding; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity

Biological Process: transport; ion transport; transmembrane transport; protein homooligomerization; potassium ion transport