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KCNC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821706

MBS821706 is an antibody targeting KCNC2. Also known as Anti-Kv3.2 Antibody. Reactive in Human, Mouse, Rat, Dog, Pig. Host: Rabbit. Rabbit polyclonal antibody to Kv3.2 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Kv3.2 (KCNC2), Polyclonal Antibody
Full Product Name
Anti-Kv3.2 Antibody
Product Gene Name
anti-KCNC2 antibody
Product Synonym Names
Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel Kv3.2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Kv3.2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
Kv3.2 peptide (MBS823560) is used for blocking the activity of Kv3.2 antibody (MBS821706)
Molecular Weight
68,317 Da
OMIM
176256
3D Structure
ModBase 3D Structure for Q96PR1
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Kv3.2. The exact sequence is proprietary.
Applications Tested/Suitable for anti-KCNC2 antibody
Western Blot (WB)
Application Notes for anti-KCNC2 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-KCNC2 antibody

Western blot analysis of Kv3.2 expression in U251MG (A) whole cell lysates.
Rabbit Anti-KCNC2 Polyclonal Antibody – Cat# MBS821706

Immunohistochemistry (IHC) of anti-KCNC2 antibody

Rabbit Anti-KCNC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821706

Other Notes

Small volumes of anti-KCNC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNC2. It may not necessarily be applicable to this product.

NCBI GI #
386781638
NCBI GeneID
3747
NCBI Accession #
NP_001247426.1
UniProt Primary Accession #
Q96PR1
UniProt Secondary Accession #
Q4LE77; Q86W09; Q8N1V9; Q96PR0; B7Z231; F5H030; J3KPP5
UniProt Related Accession #
Q96PR1
GenBank Nucleotide #
NM_001260497.1
NCBI Official Full Name
potassium voltage-gated channel subfamily C member 2 isoform 4
NCBI Official Synonym Full Names
potassium voltage-gated channel, Shaw-related subfamily, member 2
NCBI Official Symbol
KCNC2
NCBI Official Synonym Symbols
KV3.2
UniProt Protein Name
Potassium voltage-gated channel subfamily C member 2
UniProt Synonym Protein Names
Voltage-gated potassium channel Kv3.2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNC2
UniProt Entry Name
KCNC2_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily C member 2; voltage-gated potassium channel Kv3.2

NCBI Summary for KCNC2

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
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UniProt Comments for KCNC2

KCNC2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q14.1

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity

Biological Process: synaptic transmission; regulation of action potential; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization
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Research Articles on KCNC2

1. This family's complex phenotype is associated with a new chromosomal deletion, which suggests potential roles for the two genes, KCNC2 and ATXN7L3B, in human neurological disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNC2 antibody

 Reference Product  PubMed Publications
 KCNC1 antibody  >3 publications with KCNC2 and KCNC1

Pathways associated with anti-KCNC2 antibody

 Products by Pathway  Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNC2 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >2 publications with KCNC2 and Mental Disorders
 Pregnancy Complications Antibodies  >1 publications with KCNC2 and Pregnancy Complications
 Substance-Related Disorders Antibodies  >1 publications with KCNC2 and Substance-Related Disorders
 Learning Disorders Antibodies  >1 publications with KCNC2 and Learning Disorders

Organs/Tissues associated with anti-KCNC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with KCNC2 and Brain
 Kidney Antibodies  >1 publications with KCNC2 and Kidney
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