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Dopamine Beta Hydroxylase (DBH) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821730

MBS821730 is an antibody targeting DBH. Also known as Anti-Dopamine beta Hydroxylase Antibody. Reactive in Human, Mouse. Host: Rabbit. Rabbit polyclonal antibody to Dopamine beta Hydroxylase More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dopamine beta Hydroxylase (DBH), Polyclonal Antibody
Full Product Name
Anti-Dopamine beta Hydroxylase Antibody
Product Gene Name
anti-DBH antibody
Product Synonym Names
Dopamine beta-hydroxylase; Dopamine beta-monooxygenase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Dopamine beta Hydroxylase protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
Dopamine beta Hydroxylase peptide (MBS824441) is used for blocking the activity of Dopamine beta Hydroxylase antibody (MBS821730)
Molecular Weight
69,065 Da
OMIM
phenotype 609312
3D Structure
ModBase 3D Structure for P09172
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Dopamine beta Hydroxylase. The exact sequence is proprietary.
Applications Tested/Suitable for anti-DBH antibody
Western Blot (WB)
Application Notes for anti-DBH antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-DBH antibody

Western blot analysis of Dopamine beta Hydroxylase expression in HEK293T (A), SP2/0 (B), NIH3T3 (C) whole cell lysates.
Rabbit Anti-DBH Polyclonal Antibody – Cat# MBS821730

Other Notes

Small volumes of anti-DBH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DBH. It may not necessarily be applicable to this product.

NCBI GI #
116534900
NCBI GeneID
1621
NCBI Accession #
NP_000778.3
UniProt Primary Accession #
P09172
UniProt Secondary Accession #
Q5T381; Q96AG2
UniProt Related Accession #
P09172
GenBank Nucleotide #
NM_000787.3
NCBI Official Full Name
dopamine beta-hydroxylase
NCBI Official Synonym Full Names
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NCBI Official Symbol
DBH
NCBI Official Synonym Symbols
DBM
UniProt Protein Name
Dopamine beta-hydroxylase
UniProt Synonym Protein Names
Dopamine beta-monooxygenaseCleaved into the following chain:Soluble dopamine beta-hydroxylase
Protein Family
Dopamine beta-hydroxylase
UniProt Gene Name
DBH
UniProt Entry Name
DOPO_HUMAN
NCBI Protein Information
dopamine beta-hydroxylase

NCBI Summary for DBH

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
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UniProt Comments for DBH

DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family.

Protein type: EC 1.14.17.1; Motility/polarity/chemotaxis; Amino Acid Metabolism - tyrosine; Apoptosis; Oxidoreductase; Cell cycle regulation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: membrane; cytoplasm; extracellular region; integral to membrane

Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity

Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration

Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
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Research Articles on DBH

1. This study demonistrated that the Polymorphisms of dopamine beta hydroxylase is not not associated with Alzheimer's disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DBH antibody

 Reference Product  PubMed Publications
 PNMT antibody  >187 publications with DBH and PNMT
 NPY antibody  >120 publications with DBH and NPY
 COMT antibody  >77 publications with DBH and COMT
 DDC antibody  >35 publications with DBH and DDC
 MAOA antibody  >26 publications with DBH and MAOA
 MAOB antibody  >5 publications with DBH and MAOB
 CYB561 antibody  >1 publications with DBH and CYB561

Pathways associated with anti-DBH antibody

 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram

Diseases associated with anti-DBH antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >246 publications with DBH and Mental Disorders
 Nervous System Diseases Antibodies  >212 publications with DBH and Nervous System Diseases
 Hypertension Antibodies  >95 publications with DBH and Hypertension
 Movement Disorders Antibodies  >56 publications with DBH and Movement Disorders
 Hypotension Antibodies  >42 publications with DBH and Hypotension
 Pheochromocytoma Antibodies  >39 publications with DBH and Pheochromocytoma
 Depressive Disorder Antibodies  >38 publications with DBH and Depressive Disorder
 Bipolar Disorder Antibodies  >28 publications with DBH and Bipolar Disorder
 Parkinson Disease Antibodies  >27 publications with DBH and Parkinson Disease
 Neurotoxicity Syndromes Antibodies  >19 publications with DBH and Neurotoxicity Syndromes

Organs/Tissues associated with anti-DBH antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >606 publications with DBH and Brain
 Nerve Antibodies  >382 publications with DBH and Nerve
 Adrenal Gland Antibodies  >218 publications with DBH and Adrenal Gland
 Ganglia Antibodies  >158 publications with DBH and Ganglia
 Embryonic Tissue Antibodies  >29 publications with DBH and Embryonic Tissue
 Mouth Antibodies  >16 publications with DBH and Mouth
 Testis Antibodies  >7 publications with DBH and Testis
 Lymph Node Antibodies  >5 publications with DBH and Lymph Node
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