MGST2 Antibody – Rabbit Polyclonal

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

MGST2: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione. Belongs to the MAPEG family.

Protein type: EC 2.5.1.18; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, multi-pass; Xenobiotic Metabolism - metabolism by cytochrome P450; Endoplasmic reticulum; Transferase; Membrane protein, integral; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 4q28.3

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; plasma membrane; integral to membrane; nuclear envelope

Molecular Function: glutathione transferase activity; leukotriene-C4 synthase activity; enzyme activator activity; glutathione peroxidase activity

Biological Process: leukotriene biosynthetic process; positive regulation of catalytic activity; xenobiotic metabolic process; glutathione biosynthetic process; response to lipopolysaccharide; response to organic nitrogen