• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

UNG Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821775

MBS821775 is an antibody targeting UNG. Also known as Anti-UDG Antibody. Reactive in Human, Mouse, Rat, Bovine, Pig. Host: Rabbit. Rabbit polyclonal antibody to UDG More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UDG (UNG), Polyclonal Antibody
Full Product Name
Anti-UDG Antibody
Product Gene Name
anti-UNG antibody
Product Synonym Names
DGU; UNG1; UNG15; Uracil-DNA glycosylase; UDG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of UDG protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
UDG peptide (MBS823325) is used for blocking the activity of UDG antibody (MBS821775)
Molecular Weight
33,924 Da
OMIM
gene 608106
3D Structure
ModBase 3D Structure for P13051
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human UDG. The exact sequence is proprietary.
Applications Tested/Suitable for anti-UNG antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-UNG antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-UNG antibody

Western blot analysis of UDG expression in HeLa (A), Jurkat (B) whole cell lysates.
Rabbit Anti-UNG Polyclonal Antibody – Cat# MBS821775

Immunohistochemistry (IHC) of anti-UNG antibody

Immunohistochemical analysis of UDG staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-UNG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821775

Other Notes

Small volumes of anti-UNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UNG. It may not necessarily be applicable to this product.

NCBI GI #
6224979
NCBI GeneID
7374
NCBI Accession #
NP_003353.1
UniProt Primary Accession #
P13051
UniProt Secondary Accession #
O00637; O00719; Q93028; A8K5M6; B2R8Y1
UniProt Related Accession #
P13051
GenBank Nucleotide #
NM_003362.3
NCBI Official Full Name
uracil-DNA glycosylase isoform UNG1
NCBI Official Synonym Full Names
uracil-DNA glycosylase
NCBI Official Symbol
UNG
NCBI Official Synonym Symbols
DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15
UniProt Protein Name
Uracil-DNA glycosylase
Protein Family
Probable uracil-DNA glycosylase
UniProt Gene Name
UNG
UniProt Synonym Gene Names
UDG
UniProt Entry Name
UNG_HUMAN
NCBI Protein Information
uracil-DNA glycosylase; UDG; UNG; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2

NCBI Summary for UNG

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Show more

UniProt Comments for UNG

UNG: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. Belongs to the uracil-DNA glycosylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.2.27; Hydrolase

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: protein binding; uracil DNA N-glycosylase activity

Biological Process: base-excision repair, AP site formation; viral reproduction; base-excision repair; depyrimidination; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments; DNA repair; negative regulation of apoptosis

Disease: Immunodeficiency With Hyper-igm, Type 5
Show more

Research Articles on UNG

1. Data shows that cancer cells express UNG2 gene at levels similar to or higher than those seen with peripheral B cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UNG antibody

 Reference Product  PubMed Publications
 DUT antibody  >24 publications with UNG and DUT
 PCNA antibody  >13 publications with UNG and PCNA
 POLB antibody  >2 publications with UNG and POLB
 POLE antibody  >1 publications with UNG and POLE

Pathways associated with anti-UNG antibody

 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram

Diseases associated with anti-UNG antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >62 publications with UNG and Nervous System Diseases
 Breast Neoplasms Antibodies  >54 publications with UNG and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >27 publications with UNG and Cardiovascular Diseases
 Brain Diseases Antibodies  >27 publications with UNG and Brain Diseases
 Adenocarcinoma Antibodies  >25 publications with UNG and Adenocarcinoma
 Disease Models, Animal Antibodies  >22 publications with UNG and Disease Models, Animal
 Inflammation Antibodies  >20 publications with UNG and Inflammation
 Necrosis Antibodies  >18 publications with UNG and Necrosis
 Colorectal Neoplasms Antibodies  >13 publications with UNG and Colorectal Neoplasms
 Heart Diseases Antibodies  >12 publications with UNG and Heart Diseases

Organs/Tissues associated with anti-UNG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >145 publications with UNG and Blood
 Lung Antibodies  >57 publications with UNG and Lung
 Brain Antibodies  >46 publications with UNG and Brain
 Lymph Node Antibodies  >44 publications with UNG and Lymph Node
 Lymph Antibodies  >41 publications with UNG and Lymph
 Bone Antibodies  >39 publications with UNG and Bone
 Liver Antibodies  >28 publications with UNG and Liver
 Eye Antibodies  >25 publications with UNG and Eye
 Mouth Antibodies  >22 publications with UNG and Mouth
 Heart Antibodies  >22 publications with UNG and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000