Dishevelled 3 (DVL3) Antibody – Rabbit Polyclonal

DVL3: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: cytosol

Molecular Function: protein binding; protease binding; frizzled binding; protein heterodimerization activity; beta-catenin binding; receptor binding

Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin