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Amylin (IAPP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821885

MBS821885 is an antibody targeting IAPP. Also known as Anti-Amylin Antibody. Reactive in Human, Mouse, Rat, Rabbit. Host: Rabbit. Rabbit polyclonal antibody to Amylin More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Amylin (IAPP), Polyclonal Antibody
Full Product Name
Anti-Amylin Antibody
Product Gene Name
anti-IAPP antibody
Product Synonym Names
Islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Rabbit
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Amylin protein.
Preparation and Storage
Ships on blue ice. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
Amylin peptide (MBS823767) is used for blocking the activity of Amylin antibody (MBS821885)
OMIM
147940
3D Structure
ModBase 3D Structure for P10997
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Amylin. The exact sequence is proprietary.
Applications Tested/Suitable for anti-IAPP antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-IAPP antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-IAPP antibody

Western blot analysis of Amylin expression in MCF7 (A), HeLa (B), mouse kidney (C), rat kidney (D) whole cell lysates.
Rabbit Anti-IAPP Polyclonal Antibody – Cat# MBS821885

Immunohistochemistry (IHC) of anti-IAPP antibody

Immunohistochemical analysis of Amylin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-IAPP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821885

Immunofluorescence (IF) of anti-IAPP antibody

Immunofluorescent analysis of Amylin staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-IAPP Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS821885

Other Notes

Small volumes of anti-IAPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IAPP. It may not necessarily be applicable to this product.

NCBI GI #
4557655
NCBI GeneID
3375
NCBI Accession #
NP_000406.1
UniProt Primary Accession #
P10997
UniProt Secondary Accession #
Q0ZD87; Q14598
UniProt Related Accession #
P10997
GenBank Nucleotide #
NM_000415.2
NCBI Official Full Name
islet amyloid polypeptide
NCBI Official Synonym Full Names
islet amyloid polypeptide
NCBI Official Symbol
IAPP
NCBI Official Synonym Symbols
DAP; IAP
UniProt Protein Name
Islet amyloid polypeptide
UniProt Synonym Protein Names
Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
Protein Family
Islet amyloid polypeptide
UniProt Gene Name
IAPP
UniProt Synonym Gene Names
DAP
UniProt Entry Name
IAPP_HUMAN
NCBI Protein Information
islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)

NCBI Summary for IAPP

The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
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UniProt Comments for IAPP

IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: extracellular space; cell soma; extracellular region

Molecular Function: identical protein binding; hormone activity; receptor binding

Biological Process: negative regulation of cell differentiation; cell-cell signaling; apoptosis; eating behavior; sensory perception of pain; signal transduction; negative regulation of bone resorption; endocrine pancreas development
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Research Articles on IAPP

1. The mechanical properties of human islet amyloid polypeptide (hIAPP) fibrils with respect to their molecular structures as well as their amino acid sequence, were characterized.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IAPP antibody

 Reference Product  PubMed Publications
 INS antibody  >41 publications with IAPP and INS
 SCT antibody  >30 publications with IAPP and SCT
 RAMP3 antibody  >19 publications with IAPP and RAMP3
 TTR antibody  >4 publications with IAPP and TTR
 ADM antibody  >3 publications with IAPP and ADM
 GCG antibody  >3 publications with IAPP and GCG
 CALCR antibody  >3 publications with IAPP and CALCR
 CALCA antibody  >1 publications with IAPP and CALCA

Pathways associated with anti-IAPP antibody

 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram

Diseases associated with anti-IAPP antibody

 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >905 publications with IAPP and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >590 publications with IAPP and Diabetes Mellitus, Type 2
 Insulin Resistance Antibodies  >212 publications with IAPP and Insulin Resistance
 Hyperglycemia Antibodies  >172 publications with IAPP and Hyperglycemia
 Hyperinsulinism Antibodies  >119 publications with IAPP and Hyperinsulinism
 Disease Models, Animal Antibodies  >114 publications with IAPP and Disease Models, Animal
 Diabetes Mellitus, Experimental Antibodies  >87 publications with IAPP and Diabetes Mellitus, Experimental
 Inflammation Antibodies  >42 publications with IAPP and Inflammation
 Hypertension Antibodies  >34 publications with IAPP and Hypertension
 Kidney Diseases Antibodies  >19 publications with IAPP and Kidney Diseases

Organs/Tissues associated with anti-IAPP antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >795 publications with IAPP and Pancreas
 Connective Tissue Antibodies  >41 publications with IAPP and Connective Tissue
 Mixed Antibodies  >37 publications with IAPP and Mixed
 Testis Antibodies  >1 publications with IAPP and Testis
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