Rabbit Anti-GPLD1 Polyclonal Antibody – Cat# MBS821911

Western blot analysis of GPIPLD expression in A549 (A), mouse brain (B), H9C2 (C) whole cell lysates.

GPIPLD (GPLD1) Antibody – Rabbit Polyclonal

Name: GPLD1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS821911
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821911

MBS821911 is an antibody targeting GPLD1. Also known as Anti-GPIPLD Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to GPIPLD More details

$225 / 0.03 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GPIPLD (GPLD1), Polyclonal Antibody

Full Product Name

Anti-GPIPLD Antibody

Product Gene Name

anti-GPLD1 antibody

Product Synonym Names

PIGPLD1; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; GPI-PLD; GPI-specific phospholipase D

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purity/Purification

The antibody was purified by immunogen affinity chromatography.

Specificity

Recognizes endogenous levels of GPIPLD protein.

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Antibody/Peptide Pairs

GPIPLD peptide (MBS823389) is used for blocking the activity of GPIPLD antibody (MBS821911)

Molecular Weight

19,865 Da

OMIM

602515

3D Structure

ModBase 3D Structure for P80108

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPIPLD. The exact sequence is proprietary.

Applications Tested/Suitable for anti-GPLD1 antibody

Western Blot (WB)

Application Notes for anti-GPLD1 antibody

WB (1/500 - 1/1000)

Other Notes

Small volumes of anti-GPLD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPLD1. It may not necessarily be applicable to this product.

NCBI GI #

29171717

NCBI GeneID

2822

NCBI Accession #

NP_001494.2

UniProt Primary Accession #

P80108

UniProt Secondary Accession #

Q15127; Q15128; Q2M2F2; Q5T3Y0; Q7Z6T8; Q8TCV0; Q8WW82; Q96ID6; Q9H167; Q9H4M1; Q9UJC9

UniProt Related Accession #

P80108

GenBank Nucleotide #

NM_001503.3

NCBI Official Full Name

phosphatidylinositol-glycan-specific phospholipase D

NCBI Official Synonym Full Names

glycosylphosphatidylinositol specific phospholipase D1

NCBI Official Symbol

GPLD1

NCBI Official Synonym Symbols

PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1

UniProt Protein Name

Phosphatidylinositol-glycan-specific phospholipase D

UniProt Synonym Protein Names

Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; GPI-PLD; GPI-specific phospholipase D

Protein Family

Phosphatidylinositol-glycan-specific phospholipase

UniProt Gene Name

GPLD1

UniProt Synonym Gene Names

PIGPLD1; PI-G PLD; GPI-PLD; GPI-specific phospholipase D

UniProt Entry Name

PHLD_HUMAN

NCBI Protein Information

phosphatidylinositol-glycan-specific phospholipase D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D; glycoprotein phospholipase D; glycosylphosphatidylinositol specific phospholipase D1, isoform 2

NCBI Summary for GPLD1

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

UniProt Comments for GPLD1

GPLD1: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.1.4.50; Phospholipase; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Secreted

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: proteinaceous extracellular matrix; extracellular space; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; intracellular

Molecular Function: glycosylphosphatidylinositol phospholipase D activity; sodium channel regulator activity; phospholipase D activity

Biological Process: ossification; GPI anchor release; positive regulation of apoptosis; complement receptor mediated signaling pathway; positive regulation of membrane protein ectodomain proteolysis; phosphatidylcholine metabolic process; negative regulation of cell proliferation; cell migration during sprouting angiogenesis; cellular response to insulin stimulus; insulin receptor signaling pathway; response to glucose stimulus; positive regulation of secretion; chondrocyte differentiation; positive regulation of cytolysis

Research Articles on GPLD1

1. PLD1 and PLD2 mutants inhibit very-low-density lipoprotein-induced aldosterone production in HAC15 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GPLD1 antibody

Products by Pathway	Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram

Diseases associated with anti-GPLD1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>2 publications with GPLD1 and Inflammation
Heart Diseases Antibodies	>1 publications with GPLD1 and Heart Diseases
Nervous System Diseases Antibodies	>1 publications with GPLD1 and Nervous System Diseases
Liver Diseases Antibodies	>1 publications with GPLD1 and Liver Diseases

Organs/Tissues associated with anti-GPLD1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with GPLD1 and Blood
Liver Antibodies	>4 publications with GPLD1 and Liver
Kidney Antibodies	>1 publications with GPLD1 and Kidney
Pancreas Antibodies	>1 publications with GPLD1 and Pancreas
Embryonic Tissue Antibodies	>1 publications with GPLD1 and Embryonic Tissue
Lung Antibodies	>1 publications with GPLD1 and Lung