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PLC Gamma 2 (PLCG2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821936

MBS821936 is an antibody targeting PLCG2. Also known as Anti-PLC gamma 2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to PLC gamma 2 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLC gamma 2 (PLCG2), Polyclonal Antibody
Full Product Name
Anti-PLC gamma 2 Antibody
Product Gene Name
anti-PLCG2 antibody
Product Synonym Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of PLC gamma 2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
PLC gamma 2 peptide (MBS823974) is used for blocking the activity of PLC gamma 2 antibody (MBS821936)
Molecular Weight
147,870 Da
OMIM
phenotype 614878
3D Structure
ModBase 3D Structure for P16885
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PLC gamma 2. The exact sequence is proprietary.
Applications Tested/Suitable for anti-PLCG2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PLCG2 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-PLCG2 antibody

Western blot analysis of PLC gamma 2 expression in A549 (A), NIH3T3 (B), mouse brain (C), rat brain (D) whole cell lysates.
Rabbit Anti-PLCG2 Polyclonal Antibody – Cat# MBS821936

Immunohistochemistry (IHC) of anti-PLCG2 antibody

Immunohistochemical analysis of PLC gamma 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-PLCG2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821936

Other Notes

Small volumes of anti-PLCG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCG2. It may not necessarily be applicable to this product.

NCBI GI #
117320537
NCBI GeneID
5336
NCBI Accession #
NP_002652.2
UniProt Primary Accession #
P16885
UniProt Secondary Accession #
Q3ZTS2; Q59H45; Q969T5; D3DUL3
UniProt Related Accession #
P16885
GenBank Nucleotide #
NM_002661.4
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
NCBI Official Synonym Full Names
phospholipase C, gamma 2 (phosphatidylinositol-specific)
NCBI Official Symbol
PLCG2
NCBI Official Synonym Symbols
FCAS3; APLAID; PLC-IV; PLC-gamma-2
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2
Protein Family
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name
PLCG2
UniProt Synonym Gene Names
PLC-IV; PLC-gamma-2
UniProt Entry Name
PLCG2_HUMAN
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; phospholipase C-IV; phosphoinositide phospholipase C-gamma-2

NCBI Summary for PLCG2

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
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UniProt Comments for PLCG2

PLCG2: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.

Protein type: EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: plasma membrane; cytosol

Molecular Function: protein binding; signal transducer activity; phosphoinositide phospholipase C activity; phospholipase C activity

Biological Process: platelet activation; Wnt receptor signaling pathway; inositol phosphate metabolic process; phospholipid catabolic process; calcium-mediated signaling; response to lipopolysaccharide; T cell receptor signaling pathway; B cell receptor signaling pathway; activation of store-operated calcium channel activity; inositol trisphosphate biosynthetic process; regulation of gene expression; release of sequestered calcium ion into cytosol; B cell differentiation; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; innate immune response; follicular B cell differentiation; blood coagulation

Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3
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Research Articles on PLCG2

1. The relationship between upstream tyrosine kinase SYK and its target, PLCgamma2, is maximally predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLCG2 antibody

 Reference Product  PubMed Publications
 SYK antibody  >5 publications with PLCG2 and SYK
 BTK antibody  >4 publications with PLCG2 and BTK
 BLNK antibody  >2 publications with PLCG2 and BLNK
 FYN antibody  >2 publications with PLCG2 and FYN
 HCK antibody  >1 publications with PLCG2 and HCK
 LCP2 antibody  >1 publications with PLCG2 and LCP2
 LYN antibody  >1 publications with PLCG2 and LYN

Pathways associated with anti-PLCG2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram

Diseases associated with anti-PLCG2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with PLCG2 and Carcinoma
 Inflammation Antibodies  >4 publications with PLCG2 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with PLCG2 and Disease Models, Animal
 Adenocarcinoma Antibodies  >2 publications with PLCG2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with PLCG2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with PLCG2 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with PLCG2 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with PLCG2 and Cell Transformation, Neoplastic
 Infertility, Male Antibodies  >1 publications with PLCG2 and Infertility, Male
 Memory Disorders Antibodies  >1 publications with PLCG2 and Memory Disorders

Organs/Tissues associated with anti-PLCG2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with PLCG2 and Blood
 Kidney Antibodies  >1 publications with PLCG2 and Kidney
 Connective Tissue Antibodies  >1 publications with PLCG2 and Connective Tissue
 Brain Antibodies  >1 publications with PLCG2 and Brain
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