Rabbit Anti-CSNK1A1 Polyclonal Antibody – Cat# MBS822045

Western blot analysis of CK1 alpha (pY321) expression in HEK293T UV-treated (A), Jurkat (B), K562 (C), mouse liver (D), H9C2 UV-treated (E) whole cell lysates.

CK1 Alpha (Py321) (CSNK1A1) Antibody – Rabbit Polyclonal

Name: CSNK1A1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS822045
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS822045

MBS822045 is an antibody targeting CSNK1A1. Also known as Anti-CK1 alpha (pY321) Phospho Antibody. Reactive in Human, Mouse, Rat, Chicken, Pig, Zebrafish. Host: Rabbit. Rabbit polyclonal antibody to CK1 alpha (pY321) More details

$235 / 0.03 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CK1 alpha (pY321) (CSNK1A1), Polyclonal Antibody

Full Product Name

Anti-CK1 alpha (pY321) Phospho Antibody

Product Gene Name

anti-CSNK1A1 antibody

Product Synonym Names

Casein kinase I isoform alpha; CKI-alpha; CK1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Chicken, Pig, Zebrafish

Form/Format

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purity/Purification

The antibody was purified by immunogen affinity chromatography.

Specificity

Recognizes endogenous levels of CK1 alpha (pY321) protein.

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Antibody/Peptide Pairs

CK1 alpha (pY321) peptide (MBS823080) is used for blocking the activity of CK1 alpha (pY321) antibody (MBS822045)

Molecular Weight

37,567 Da

OMIM

600505

3D Structure

ModBase 3D Structure for P48729

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CK1 alpha. The exact sequence is proprietary.

Applications Tested/Suitable for anti-CSNK1A1 antibody

Western Blot (WB)

Application Notes for anti-CSNK1A1 antibody

WB (1/500 - 1/1000)

Other Notes

Small volumes of anti-CSNK1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CSNK1A1. It may not necessarily be applicable to this product.

NCBI GI #

68303575

NCBI GeneID

1452

NCBI Accession #

NP_001020276.1

UniProt Primary Accession #

P48729

UniProt Secondary Accession #

Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3; D3DQG0; D3DQG1

UniProt Related Accession #

P48729

GenBank Nucleotide #

NM_001025105.2

NCBI Official Full Name

casein kinase I isoform alpha isoform 1

NCBI Official Synonym Full Names

casein kinase 1, alpha 1

NCBI Official Symbol

CSNK1A1

NCBI Official Synonym Symbols

CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p

UniProt Protein Name

Casein kinase I isoform alpha

UniProt Synonym Protein Names

CK1

Protein Family

Casein kinase

UniProt Gene Name

CSNK1A1

UniProt Synonym Gene Names

CKI-alpha

UniProt Entry Name

KC1A_HUMAN

NCBI Protein Information

casein kinase I isoform alpha; CKI-alpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p

UniProt Comments for CSNK1A1

CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.

Protein type: Protein kinase, CK1; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: centrosome; membrane; cytoplasm; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity

Biological Process: mitosis; regulation of cell shape; peptidyl-serine phosphorylation; cell surface receptor linked signal transduction; Wnt receptor signaling pathway; cell division; signal transduction; protein amino acid phosphorylation; phagocytosis

Research Articles on CSNK1A1

1. Data indicate that protein S phosphorylation by casein kinase 1 (CK1) and casein kinase 2 (CK2) increased activated proten C cofactor activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CSNK1A1 antibody

Reference Product	PubMed Publications
CTNNB1 antibody	>5 publications with CSNK1A1 and CTNNB1
AXIN2 antibody	>1 publications with CSNK1A1 and AXIN2
TP53 antibody	>1 publications with CSNK1A1 and TP53

Pathways associated with anti-CSNK1A1 antibody

Products by Pathway	Pathway Diagram
AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies	AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies	APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies	APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies	AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies	AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
Beta-catenin Phosphorylation Cascade Pathway antibodies	Beta-catenin Phosphorylation Cascade Pathway Diagram
Canonical Wnt Signaling Pathway antibodies	Canonical Wnt Signaling Pathway Diagram
Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies	Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
FoxO Family Signaling Pathway antibodies	FoxO Family Signaling Pathway Diagram

Diseases associated with anti-CSNK1A1 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>2 publications with CSNK1A1 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>2 publications with CSNK1A1 and Cell Transformation, Neoplastic
Disease Models, Animal Antibodies	>1 publications with CSNK1A1 and Disease Models, Animal
Esophageal Neoplasms Antibodies	>1 publications with CSNK1A1 and Esophageal Neoplasms
Anemia Antibodies	>1 publications with CSNK1A1 and Anemia
Inflammation Antibodies	>1 publications with CSNK1A1 and Inflammation

Organs/Tissues associated with anti-CSNK1A1 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with CSNK1A1 and Lung
Lymph Node Antibodies	>1 publications with CSNK1A1 and Lymph Node
Bone Antibodies	>1 publications with CSNK1A1 and Bone
Intestine Antibodies	>1 publications with CSNK1A1 and Intestine
Skin Antibodies	>1 publications with CSNK1A1 and Skin
Blood Antibodies	>1 publications with CSNK1A1 and Blood
Brain Antibodies	>1 publications with CSNK1A1 and Brain