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TNFSF13 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS822226

MBS822226 is an antibody targeting TNFSF13. Also known as Anti-CD256 Antibody. Reactive in Human, Mouse, Rat, Bovine, Dog, Pig. Host: Rabbit. Rabbit polyclonal antibody to CD256 More details

$225 / 0.03 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
CD256 (TNFSF13), Polyclonal Antibody
Full Product Name
Anti-CD256 Antibody
Product Gene Name
anti-TNFSF13 antibody
Product Synonym Names
APRIL; TALL2; ZTNF2; Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD256
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of CD256 protein.
Preparation and Storage
Ships on blue ice. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
CD256 peptide (MBS822439) is used for blocking the activity of CD256 antibody (MBS822226)
Molecular Weight
36,589 Da
OMIM
604472
3D Structure
ModBase 3D Structure for O75888
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD256. The exact sequence is proprietary.
Applications Tested/Suitable for anti-TNFSF13 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-TNFSF13 antibody
WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-TNFSF13 antibody

Western blot analysis of CD256 expression in HEK293T (A), Hela (B), H446 (C), mouse brain (D), mouse kidney (E), rat brain (F), rat kidney (G) whole cell lysates.
Rabbit Anti-TNFSF13 Polyclonal Antibody – Cat# MBS822226

Immunohistochemistry (IHC) of anti-TNFSF13 antibody

Immunohistochemical analysis of CD256 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-TNFSF13 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS822226

Immunofluorescence (IF) of anti-TNFSF13 antibody

Immunofluorescent analysis of CD256 staining in H9C2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-TNFSF13 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS822226

Other Notes

Small volumes of anti-TNFSF13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFSF13. It may not necessarily be applicable to this product.

NCBI GI #
310750387
NCBI GeneID
8741
NCBI Accession #
NP_001185552.1
UniProt Primary Accession #
O75888
UniProt Secondary Accession #
Q541E1; Q5U0G8; Q96HV6; Q9P1M8; Q9P1M9; A8MYD5; B4DVT2
UniProt Related Accession #
O75888
GenBank Nucleotide #
NM_001198623.1
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 13 isoform zeta
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol
TNFSF13
NCBI Official Synonym Symbols
APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13
UniProt Synonym Protein Names
A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256
Protein Family
Tumor necrosis factor ligand superfamily
UniProt Gene Name
TNFSF13
UniProt Synonym Gene Names
APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1
UniProt Entry Name
TNF13_HUMAN
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2

NCBI Summary for TNFSF13

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
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UniProt Comments for TNFSF13

TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol; external side of plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; gene expression; signal transduction; positive regulation of isotype switching to IgA isotypes
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Research Articles on TNFSF13

1. Our results suggest that an elevated level of BAFF/APRIL drives the maturation of B cells, subsequently leading to IgA2 class switching, and possibly to the development of interstitial lung disease in patients with mixed connective tissue disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFSF13 antibody

 Reference Product  PubMed Publications
 TNFSF13B antibody  >95 publications with TNFSF13 and TNFSF13B
 TNFRSF17 antibody  >60 publications with TNFSF13 and TNFRSF17
 TNFRSF13B antibody  >45 publications with TNFSF13 and TNFRSF13B
 SET antibody  >8 publications with TNFSF13 and SET
 FURIN antibody  >5 publications with TNFSF13 and FURIN

Pathways associated with anti-TNFSF13 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HuR Stabilizes MRNA Pathway antibodies  HuR Stabilizes MRNA Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-TNFSF13 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >216 publications with TNFSF13 and Necrosis
 Inflammation Antibodies  >20 publications with TNFSF13 and Inflammation
 Disease Models, Animal Antibodies  >13 publications with TNFSF13 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >11 publications with TNFSF13 and Cardiovascular Diseases
 Colorectal Neoplasms Antibodies  >11 publications with TNFSF13 and Colorectal Neoplasms
 Nervous System Diseases Antibodies  >10 publications with TNFSF13 and Nervous System Diseases
 Kidney Diseases Antibodies  >6 publications with TNFSF13 and Kidney Diseases
 Liver Neoplasms Antibodies  >5 publications with TNFSF13 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with TNFSF13 and Neoplasms, Experimental
 Liver Diseases Antibodies  >4 publications with TNFSF13 and Liver Diseases

Organs/Tissues associated with anti-TNFSF13 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >163 publications with TNFSF13 and Blood
 Bone Antibodies  >21 publications with TNFSF13 and Bone
 Spleen Antibodies  >16 publications with TNFSF13 and Spleen
 Lung Antibodies  >11 publications with TNFSF13 and Lung
 Kidney Antibodies  >10 publications with TNFSF13 and Kidney
 Lymph Node Antibodies  >9 publications with TNFSF13 and Lymph Node
 Skin Antibodies  >7 publications with TNFSF13 and Skin
 Liver Antibodies  >6 publications with TNFSF13 and Liver
 Vascular Antibodies  >5 publications with TNFSF13 and Vascular
 Mouth Antibodies  >3 publications with TNFSF13 and Mouth
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