POLR1A Antibody – Rabbit Polyclonal

POLR1A: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Belongs to the RNA polymerase beta' chain family.

Protein type: Nucleotide Metabolism - pyrimidine; Transferase; Transcription initiation complex; Nucleotide Metabolism - purine; Nucleolus; EC 2.7.7.6

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus; DNA-directed RNA polymerase I complex

Molecular Function: protein binding; DNA binding; zinc ion binding

Biological Process: negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic

Disease: Acrofacial Dysostosis, Cincinnati Type