ATP6V1H Antibody – Rabbit Polyclonal

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

ATP6V1H: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: lysosomal membrane; plasma membrane; cytosol; vacuolar proton-transporting V-type ATPase, V1 domain

Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; enzyme regulator activity

Biological Process: vacuolar acidification; interaction with host; viral reproduction; regulation of catalytic activity; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; endocytosis; transmembrane transport; regulation of defense response to virus by virus