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LPAR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS822320

MBS822320 is an antibody targeting LPAR3. Also known as Anti-EDG7 Antibody. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to EDG7 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EDG7 (LPAR3), Polyclonal Antibody
Full Product Name
Anti-EDG7 Antibody
Product Gene Name
anti-LPAR3 antibody
Product Synonym Names
EDG7; LPA3; Lysophosphatidic acid receptor 3; LPA receptor 3; LPA-3; Lysophosphatidic acid receptor Edg-7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of EDG7 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
EDG7 peptide (MBS823835) is used for blocking the activity of EDG7 antibody (MBS822320)
Molecular Weight
40,128 Da
OMIM
605106
3D Structure
ModBase 3D Structure for Q9UBY5
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EDG7. The exact sequence is proprietary.
Applications Tested/Suitable for anti-LPAR3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LPAR3 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-LPAR3 antibody

Western blot analysis of EDG7 expression in HepG2 (A), NT2D1 (B) whole cell lysates.
Rabbit Anti-LPAR3 Polyclonal Antibody – Cat# MBS822320

Immunohistochemistry (IHC) of anti-LPAR3 antibody

Immunohistochemical analysis of EDG7 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-LPAR3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS822320

Other Notes

Small volumes of anti-LPAR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LPAR3. It may not necessarily be applicable to this product.

NCBI GI #
6912348
NCBI GeneID
23566
NCBI Accession #
NP_036284.1
UniProt Primary Accession #
Q9UBY5
UniProt Secondary Accession #
A0AVA3
UniProt Related Accession #
Q9UBY5
GenBank Nucleotide #
NM_012152.2
NCBI Official Full Name
lysophosphatidic acid receptor 3
NCBI Official Synonym Full Names
lysophosphatidic acid receptor 3
NCBI Official Symbol
LPAR3
NCBI Official Synonym Symbols
EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3
UniProt Protein Name
Lysophosphatidic acid receptor 3
UniProt Synonym Protein Names
Lysophosphatidic acid receptor Edg-7
Protein Family
Lysophosphatidic acid receptor
UniProt Gene Name
LPAR3
UniProt Synonym Gene Names
EDG7; LPA3; LPA receptor 3; LPA-3
UniProt Entry Name
LPAR3_HUMAN
NCBI Protein Information
lysophosphatidic acid receptor 3; LPA-3; LPA receptor 3; LPA receptor EDG7; lysophosphatidic acid receptor Edg-7; endothelial cell differentiation gene 7; calcium-mobilizing lysophosphatidic acid receptor LP-A3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7

NCBI Summary for LPAR3

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
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UniProt Comments for LPAR3

EDG7: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Belongs to the G-protein coupled receptor 1 family.

Protein type: Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: axon; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; phospholipid binding; G-protein alpha-subunit binding; lipid binding

Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); elevation of cytosolic calcium ion concentration; activation of MAPK activity; bleb formation; positive regulation of calcium ion transport; positive regulation of collateral sprouting
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Research Articles on LPAR3

1. Findings indicate lysophosphatidic acid (LPA)-lysophosphatidic acid receptor-Galpha13 signaling node as a therapeutic target for pancreatic cancer treatment and control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LPAR3 antibody

 Reference Product  PubMed Publications
 LPAR4 antibody  >2 publications with LPAR3 and LPAR4
 EGFR antibody  >1 publications with LPAR3 and EGFR
 TBXA2R antibody  >1 publications with LPAR3 and TBXA2R
 LPAR6 antibody  >1 publications with LPAR3 and LPAR6

Pathways associated with anti-LPAR3 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-LPAR3 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >4 publications with LPAR3 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with LPAR3 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >2 publications with LPAR3 and Neoplasm Metastasis
 Liver Diseases Antibodies  >2 publications with LPAR3 and Liver Diseases
 Fibrosis Antibodies  >1 publications with LPAR3 and Fibrosis
 Mammary Neoplasms, Animal Antibodies  >1 publications with LPAR3 and Mammary Neoplasms, Animal
 Mammary Neoplasms, Experimental Antibodies  >1 publications with LPAR3 and Mammary Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with LPAR3 and Breast Neoplasms

Organs/Tissues associated with anti-LPAR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with LPAR3 and Liver
 Lung Antibodies  >4 publications with LPAR3 and Lung
 Bone Antibodies  >1 publications with LPAR3 and Bone
 Connective Tissue Antibodies  >1 publications with LPAR3 and Connective Tissue
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