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TGF Beta 3 (TGFB3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS822335

MBS822335 is an antibody targeting TGFB3. Also known as Anti-TGF beta 3 Antibody. Reactive in Human, Mouse, Rat, Dog, Monkey. Host: Rabbit. Rabbit polyclonal antibody to TGF beta 3 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGF beta 3 (TGFB3), Polyclonal Antibody
Full Product Name
Anti-TGF beta 3 Antibody
Product Gene Name
anti-TGFB3 antibody
Product Synonym Names
Transforming growth factor beta-3; TGF-beta-3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of TGF beta 3 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
TGF beta 3 peptide (MBS823271) is used for blocking the activity of TGF beta 3 antibody (MBS822335)
Molecular Weight
35,708 Da
OMIM
gene 615582
3D Structure
ModBase 3D Structure for P10600
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TGF beta 3. The exact sequence is proprietary.
Applications Tested/Suitable for anti-TGFB3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TGFB3 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-TGFB3 antibody

Western blot analysis of TGF beta 3 expression in MCF7 (A), NIH3T3 (B), PC12 (C) whole cell lysates.
Rabbit Anti-TGFB3 Polyclonal Antibody – Cat# MBS822335

Immunohistochemistry (IHC) of anti-TGFB3 antibody

Immunohistochemical analysis of TGF beta 3 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-TGFB3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS822335

Other Notes

Small volumes of anti-TGFB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFB3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Primary Accession #
P10600
UniProt Secondary Accession #
Q8WV88
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.3
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor, beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; RNHF; ARVD1; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
Protein Family
Transforming growth factor
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3

NCBI Summary for TGFB3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

UniProt Comments for TGFB3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Secreted, signal peptide; Cell development/differentiation; Secreted

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; SMAD protein nuclear translocation; female pregnancy; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; uterine wall breakdown; positive regulation of filopodium formation; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; positive regulation of cell division; regulation of MAPKKK cascade; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Research Articles on TGFB3

1. These results unequivocally demonstrate that human TGF-beta3 elicits bone induction by up-regulation of endogenous BMP-2 and is blocked by hNoggin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TGFB3 antibody

 Reference Product  PubMed Publications
 TGFB2 antibody  >571 publications with TGFB3 and TGFB2
 EGF antibody  >21 publications with TGFB3 and EGF
 SERPINE1 antibody  >16 publications with TGFB3 and SERPINE1
 TGFBR2 antibody  >10 publications with TGFB3 and TGFBR2
 TGFBR1 antibody  >9 publications with TGFB3 and TGFBR1
 SMAD5 antibody  >2 publications with TGFB3 and SMAD5
 TIMP1 antibody  >1 publications with TGFB3 and TIMP1
 ACVRL1 antibody  >1 publications with TGFB3 and ACVRL1
 FN1 antibody  >1 publications with TGFB3 and FN1

Pathways associated with anti-TGFB3 antibody

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram

Diseases associated with anti-TGFB3 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >190 publications with TGFB3 and Fibrosis
 Cleft Palate Antibodies  >106 publications with TGFB3 and Cleft Palate
 Disease Models, Animal Antibodies  >104 publications with TGFB3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >87 publications with TGFB3 and Cardiovascular Diseases
 Inflammation Antibodies  >81 publications with TGFB3 and Inflammation
 Necrosis Antibodies  >64 publications with TGFB3 and Necrosis
 Heart Diseases Antibodies  >53 publications with TGFB3 and Heart Diseases
 Hypertrophy Antibodies  >39 publications with TGFB3 and Hypertrophy
 Breast Neoplasms Antibodies  >38 publications with TGFB3 and Breast Neoplasms
 Lung Diseases Antibodies  >36 publications with TGFB3 and Lung Diseases

Organs/Tissues associated with anti-TGFB3 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >357 publications with TGFB3 and Bone
 Connective Tissue Antibodies  >247 publications with TGFB3 and Connective Tissue
 Embryonic Tissue Antibodies  >143 publications with TGFB3 and Embryonic Tissue
 Bone Marrow Antibodies  >128 publications with TGFB3 and Bone Marrow
 Mouth Antibodies  >120 publications with TGFB3 and Mouth
 Heart Antibodies  >80 publications with TGFB3 and Heart
 Lung Antibodies  >76 publications with TGFB3 and Lung
 Eye Antibodies  >67 publications with TGFB3 and Eye
 Brain Antibodies  >65 publications with TGFB3 and Brain
 Liver Antibodies  >51 publications with TGFB3 and Liver
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